Search Results

Overview

Uniprot IDQ9JHI5
Protein NameIsovaleryl-CoA dehydrogenase, mitochondrial
Gene NameIvd
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
184 MKLKAEKKGDHYVLN
56 QLRHTISKFLQENLA
76 IDQTNDFKNLREFWK

Function

A mitochondrial matrix enzyme that catalyzes the third step in leucine catabolism, where isovaleryl-CoA (3-methylbutanoyl-CoA) is metabolized to 3-methylbut-2-enoyl-CoA. To a lesser extent, it also participates in the first step in fatty acid beta-oxidation, in which it catalyzes the proR-proR stereospecific alpha,beta-dehydrogenation of other saturated short-chain acyl-CoA thioesters such as pentanoyl-CoA, hexanoyl-CoA and butanoyl-CoA, using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor

Protein Sequence

10 MATAIRLLGR 20 RVSSWRLRPS 30 PSPLAVPRRA 40 HSILPVDDDI 50 NGLNEEQKQL 60 RHTISKFLQE 70 NLAPKAQEID 80 QTNDFKNLRE 90 FWKQLGSLGV 100 LGITAPVQYG 110 GSGLGYLEHV 120 LVMEEISRAS 130 GAVGLSYGAH 140 SNLCVNQIVR 150 NGNEAQKEKY 160 LPKLISGEFI 170 GALAMSEPNA 180 GSDVVSMKLK 190 AEKKGDHYVL 200 NGNKFWITNG 210 PDADILVVYA 220 KTDLTAVPAS 230 RGITAFIVEK 240 GMPGFSTSKK 250 LDKLGMRGSN 260 TCELVFEDCK 270 VPAANVLSQE 280 SKGVYVLMSG 290 LDLERLVLAG 300 GPLGIMQAVL 310 DHTIPYLHVR 320 EAFGQKIGQF 330 QLMQGKMADM 340 YTRLMASRQY 350 VYNVAKACDE 360 GHIIPKDCAG 370 VILYAAECAT 380 QVALDGIQCL 390 GGNGYINDFP 400 MGRFLRDAKL 410 YEIGAGTSEV 420 RRLVIGRAFN ADFR

Gene Ontology

Classification GO ID Description
Molecular Function GO:0050660 flavin adenine dinucleotide binding
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0031966 mitochondrial membrane
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0008470 3-methylbutanoyl-CoA dehydrogenase activity
Molecular Function GO:0042802 identical protein binding
Biological Process GO:0009083 branched-chain amino acid catabolic process
Biological Process GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase
Biological Process GO:0006552 L-leucine catabolic process

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.