Search Results
Overview
| Uniprot ID | Q9JI91 |
|---|---|
| Protein Name | Alpha-actinin-2 |
| Gene Name | Actn2 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 102 | HKIANVNKALDYIAS |
| 110 | ALDYIASKGVKLVSI |
| 202 | PDLIDYSKLNKDDPI |
| 239 | EDIVNTPKPDERAIM |
| 271 | TAANRICKVLAVNQE |
| 311 | LENRTPEKTMQAMQK |
| 443 | EVRALLRKHEAFESD |
| 54 | WCNSHLRKAGTQIEN |
| 615 | RNKWDKVKQLVPVRD |
| 711 | EALVFDNKHTNYTME |
| 748 | QILTRDAKGITQEQM |
| 96 | RGKMRFHKIANVNKA |
Function
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity)
Protein Sequence
10
MNQIEPGVQY
20
NYVYDEDEYM
30
IQEEEWDRDL
40
LLDPAWEKQQ
50
RKTFTAWCNS
60
HLRKAGTQIE
70
NIEEDFRNGL
80
KLMLLLEVIS
90
GERLPKPDRG
100
KMRFHKIANV
110
NKALDYIASK
120
GVKLVSIGAE
130
EIVDGNVKMT
140
LGMIWTIILR
150
FAIQDISVEE
160
TSAKEGLLLW
170
CQRKTAPYRN
180
VNIQNFHTSW
190
KDGLGLCALI
200
HRHRPDLIDY
210
SKLNKDDPIG
220
NINLAMEIAE
230
KHLDIPKMLD
240
AEDIVNTPKP
250
DERAIMTYVS
260
CFYHAFAGAE
270
QAETAANRIC
280
KVLAVNQENE
290
RLMEEYERLA
300
SELLEWIRRT
310
IPWLENRTPE
320
KTMQAMQKKL
330
EDFRDYRRKH
340
KPPKVQEKCQ
350
LEINFNTLQT
360
KLRISNRPAF
370
MPSEGKMVSD
380
IAGAWQRLEQ
390
AEKGYEEWLL
400
NEIRRLERLE
410
HLAEKFRQKA
420
STHETWAYGK
430
EQILLQKDYE
440
SASLTEVRAL
450
LRKHEAFESD
460
LAAHQDRVEQ
470
IAAIAQELNE
480
LDYHDAVNVN
490
DRCQKICDQW
500
DRLGTLTQKR
510
REALERTEKL
520
LETIDQLHLE
530
FAKRAAPFNN
540
WMEGAMEDLQ
550
DMFIVHSIEE
560
IQSLITAHEQ
570
FKATLPEADG
580
ERQSILAIQN
590
EVEKVIQSYS
600
IRISSSNPYS
610
TVTMDELRNK
620
WDKVKQLVPV
630
RDQSLQEELA
640
RQHANERLRR
650
QFAAQANAIG
660
PWIQNKMEEI
670
ARSSIQITGA
680
LEDQMNQLKQ
690
YEHNIINYKN
700
NIDKLEGDHQ
710
LIQEALVFDN
720
KHTNYTMEHI
730
RVGWELLLTT
740
IARTINEVET
750
QILTRDAKGI
760
TQEQMNEFRA
770
SFNHFDRRKN
780
GLMDHEDFRA
790
CLISMGYDLG
800
EAEFARIMTL
810
VDPNGQGTVT
820
FQSFIDFMTR
830
ETADTDTAEQ
840
VIASFRILAS
850
DKPYILAEEL
860
RRELPPDQAQ
870
YCIKRMPPYS
880
GPGSVPGALD
890
YTAFSSALYG
ESDL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030054 | cell junction |
| Cellular Component | GO:0042995 | cell projection |
| Cellular Component | GO:0030864 | cortical actin cytoskeleton |
| Cellular Component | GO:0030175 | filopodium |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0098871 | postsynaptic actin cytoskeleton |
| Cellular Component | GO:0098839 | postsynaptic density membrane |
| Cellular Component | GO:0099092 | postsynaptic density, intracellular component |
| Cellular Component | GO:0030017 | sarcomere |
| Cellular Component | GO:0005865 | striated muscle thin filament |
| Cellular Component | GO:0030018 | Z disc |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0099103 | channel activator activity |
| Molecular Function | GO:0008092 | cytoskeletal protein binding |
| Molecular Function | GO:0051373 | FATZ binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0030274 | LIM domain binding |
| Molecular Function | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0030674 | protein-macromolecule adaptor activity |
| Molecular Function | GO:0098973 | structural constituent of postsynaptic actin cytoskeleton |
| Molecular Function | GO:0031432 | titin binding |
| Molecular Function | GO:0070080 | titin Z domain binding |
| Molecular Function | GO:0003713 | transcription coactivator activity |
| Molecular Function | GO:0044325 | transmembrane transporter binding |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0051695 | actin filament uncapping |
| Biological Process | GO:0055013 | cardiac muscle cell development |
| Biological Process | GO:0048041 | focal adhesion assembly |
| Biological Process | GO:0030035 | microspike assembly |
| Biological Process | GO:0055001 | muscle cell development |
| Biological Process | GO:0006936 | muscle contraction |
| Biological Process | GO:0043267 | negative regulation of potassium ion transport |
| Biological Process | GO:2000009 | negative regulation of protein localization to cell surface |
| Biological Process | GO:0086097 | phospholipase C-activating angiotensin-activated signaling pathway |
| Biological Process | GO:2001137 | positive regulation of endocytic recycling |
| Biological Process | GO:0043268 | positive regulation of potassium ion transport |
| Biological Process | GO:0072659 | protein localization to plasma membrane |
| Biological Process | GO:0042391 | regulation of membrane potential |
| Biological Process | GO:0045214 | sarcomere organization |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.