Search Results
Overview
| Uniprot ID | Q9JJW5 |
|---|---|
| Protein Name | Myozenin-2 |
| Gene Name | Myoz2 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 146 | FNTTAVPKYYRSPWE |
| 176 | KLFKPEGKAELRDYR |
| 67 | MRQRRSDKYTFENFQ |
Function
Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis
Protein Sequence
10
MLSHSAMVKQ
20
RKQQASAITK
30
EIHGHDVDGM
40
DLGKKVSIPR
50
DIMIEELSHF
60
SNRGARLFKM
70
RQRRSDKYTF
80
ENFQYESRAQ
90
INHNIAMQNG
100
RVDGSNLEGG
110
SQQGPSTPPN
120
TPDPRSPPNP
130
ENIAPGYSGP
140
LKEIPPERFN
150
TTAVPKYYRS
160
PWEQAIGSDP
170
ELLEALYPKL
180
FKPEGKAELR
190
DYRSFNRVAT
200
PFGGFEKASK
210
MVKFKVPDFE
220
LLLLTDPRFL
230
AFANPLSGRR
240
CFNRAPKGWV
250
SENIPVVITT
260
EPTEDATVPE
SDDL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0030018 | Z disc |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0051373 | FATZ binding |
| Molecular Function | GO:0031433 | telethonin binding |
| Biological Process | GO:0070885 | negative regulation of calcineurin-NFAT signaling cascade |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0045214 | sarcomere organization |
| Biological Process | GO:0043503 | skeletal muscle fiber adaptation |
| Biological Process | GO:0007519 | skeletal muscle tissue development |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.