Search Results
Overview
| Uniprot ID | Q9JK37 |
|---|---|
| Protein Name | Myozenin-1 |
| Gene Name | Myoz1 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 11 | SGTPAPNKRRKSSKL |
| 17 | NKRRKSSKLIMELTG |
| 36 | SSGLNLGKKISVPRD |
Function
Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis
Protein Sequence
10
MPLSGTPAPN
20
KRRKSSKLIM
30
ELTGGGRESS
40
GLNLGKKISV
50
PRDVMLEELS
60
LLTNRGSKMF
70
KLRQMRVEKF
80
IYENHPDVFS
90
DSSMDHFQKF
100
LPTVGGQLET
110
AGQGFSYGKG
120
SSGGQAGSSG
130
SAGQYGSDRH
140
QQGSGFGAGG
150
SGGPGGQAGG
160
GGAPGTVGLG
170
EPGSGDQAGG
180
DGKHVTVFKT
190
YISPWDRAMG
200
VDPQQKVELG
210
IDLLAYGAKA
220
ELPKYKSFNR
230
TAMPYGGYEK
240
ASKRMTFQMP
250
KFDLGPLLSE
260
PLVLYNQNLS
270
NRPSFNRTPI
280
PWLSSGEHVD
290
YNVDVGIPLD
GETEEL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0031143 | pseudopodium |
| Cellular Component | GO:0030018 | Z disc |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0042805 | actinin binding |
| Molecular Function | GO:0051373 | FATZ binding |
| Molecular Function | GO:0140693 | molecular condensate scaffold activity |
| Molecular Function | GO:0004865 | protein serine/threonine phosphatase inhibitor activity |
| Molecular Function | GO:0031433 | telethonin binding |
| Biological Process | GO:0070885 | negative regulation of calcineurin-NFAT signaling cascade |
| Biological Process | GO:0043417 | negative regulation of skeletal muscle tissue regeneration |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0045214 | sarcomere organization |
| Biological Process | GO:0043503 | skeletal muscle fiber adaptation |
| Biological Process | GO:0007519 | skeletal muscle tissue development |
| Biological Process | GO:0042060 | wound healing |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.