Search Results
Overview
| Uniprot ID | Q9JKS4 |
|---|---|
| Protein Name | LIM domain-binding protein 3 |
| Gene Name | Ldb3 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 21 | GFRLQGGKDFNMPLT |
| 218 | YQMSLRGKASGAGLL |
| 252 | AVIKTQSKPEDEADE |
| 500 | SQKFAPGKSTTTVSK |
| 507 | KSTTTVSKQTLPRGA |
| 82 | NLSLTLQKSKRPIPI |
Function
May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton
Protein Sequence
10
MSYSVTLTGP
20
GPWGFRLQGG
30
KDFNMPLTIS
40
RITPGSKAAQ
50
SQLSQGDLVV
60
AIDGVNTDTM
70
THLEAQNKIK
80
SASYNLSLTL
90
QKSKRPIPIS
100
TTAPPIQSPL
110
PVIPHQKDPA
120
LDTNGSLATP
130
SPSPEARASP
140
GALEFGDTFS
150
SSFSQTSVCS
160
PLMEASGPVL
170
PLGSPVAKAS
180
SEGAQGSVSP
190
KVLPGPSQPR
200
QYNNPIGLYS
210
AETLREMAQM
220
YQMSLRGKAS
230
GAGLLGGSLP
240
VKDLAVDSAS
250
PVYQAVIKTQ
260
SKPEDEADEW
270
ARRSSNLQSR
280
SFRILAQMTG
290
TEYMQDPDEE
300
ALRRSSTPIE
310
HAPVCTSQAT
320
SPLLPASAQS
330
PAAASPIAAS
340
PTLATAAATH
350
AAAASAAGPA
360
ASPVENPRPQ
370
ASAYSPAAAA
380
SPAPSAHTSY
390
SEGPAAPAPK
400
PRVVTTASIR
410
PSVYQPVPAS
420
SYSPSPGANY
430
SPTPYTPSPA
440
PAYTPSPAPT
450
YTPSPAPTYS
460
PSPAPAYTPS
470
PAPNYTPTPS
480
AAYSGGPSES
490
ASRPPWVTDD
500
SFSQKFAPGK
510
STTTVSKQTL
520
PRGAPAYNPT
530
GPQVTPLARG
540
TFQRAERFPA
550
SSRTPLCGHC
560
NNVIRGPFLV
570
AMGRSWHPEE
580
FNCAYCKTSL
590
ADVCFVEEQN
600
NVYCERCYEQ
610
FFAPICAKCN
620
TKIMGEVMHA
630
LRQTWHTTCF
640
VCAACKKPFG
650
NSLFHMEDGE
660
PYCEKDYINL
670
FSTKCHGCDF
680
PVEAGDKFIE
690
ALGHTWHDTC
700
FICAVCHVNL
710
EGQPFYSKKD
720
KPLCKKHAHA
INV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0003779 | actin binding |
| Cellular Component | GO:0005912 | adherens junction |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0031941 | filamentous actin |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0031143 | pseudopodium |
| Cellular Component | GO:0001725 | stress fiber |
| Cellular Component | GO:0030018 | Z disc |
| Molecular Function | GO:0008092 | cytoskeletal protein binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0051371 | muscle alpha-actinin binding |
| Molecular Function | GO:0005080 | protein kinase C binding |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0007507 | heart development |
| Biological Process | GO:0061061 | muscle structure development |
| Biological Process | GO:0045214 | sarcomere organization |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.