Search Results
Overview
| Uniprot ID | Q9JLT4 |
|---|---|
| Protein Name | Thioredoxin reductase 2, mitochondrial |
| Gene Name | Txnrd2 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 175 | RGVDKGGKATLLSAE |
| 329 | TRTLNLEKAGISTNP |
| 337 | AGISTNPKNQKIIVD |
Function
Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis (By similarity). Maintains thioredoxin in a reduced state. May play a role in redox-regulated cell signaling (By similarity)
Protein Sequence
10
MVAAMVAALR
20
GPSRRFRPRT
30
RALTRGTRGA
40
ASAAGGQQSF
50
DLLVIGGGSG
60
GLACAKEAAQ
70
LGKKVAVADY
80
VEPSPRGTKW
90
GLGGTCVNVG
100
CIPKKLMHQA
110
ALLGGMIRDA
120
HHYGWEVAQP
130
VQHNWKTMAE
140
AVQNHVKSLN
150
WGHRVQLQDR
160
KVKYFNIKAS
170
FVDEHTVRGV
180
DKGGKATLLS
190
AEHIVIATGG
200
RPRYPTQVKG
210
ALEYGITSDD
220
IFWLKESPGK
230
TLVVGASYVA
240
LECAGFLTGI
250
GLDTTVMMRS
260
IPLRGFDQQM
270
SSLVTEHMES
280
HGTQFLKGCV
290
PSHIKKLPTN
300
QLQVTWEDHA
310
SGKEDTGTFD
320
TVLWAIGRVP
330
ETRTLNLEKA
340
GISTNPKNQK
350
IIVDAQEATS
360
VPHIYAIGDV
370
AEGRPELTPT
380
AIKAGKLLAQ
390
RLFGKSSTLM
400
DYSNVPTTVF
410
TPLEYGCVGL
420
SEEEAVALHG
430
QEHVEVYHAY
440
YKPLEFTVAD
450
RDASQCYIKM
460
VCMREPPQLV
470
LGLHFLGPNA
480
GEVTQGFALG
490
IKCGASYAQV
500
MQTVGIHPTC
510
SEEVVKLHIS
520
KRSGLEPTVT
GCUG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0043025 | neuronal cell body |
| Molecular Function | GO:0050660 | flavin adenine dinucleotide binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0004791 | thioredoxin-disulfide reductase (NADPH) activity |
| Biological Process | GO:0045454 | cell redox homeostasis |
| Biological Process | GO:0007507 | heart development |
| Biological Process | GO:0030097 | hemopoiesis |
| Biological Process | GO:0000305 | response to oxygen radical |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.