Overview
| Uniprot ID | Q9MZ15 |
|---|
| Protein Name | Non-selective voltage-gated ion channel VDAC2 |
|---|
| Gene Name | VDAC2 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 120 |
TFSPNTGKKSGKIKS |
| 277 |
LSALVDGKSINAGGH |
| 39 |
GFGFGLVKLDVKTKS |
| 45 |
VKLDVKTKSCSGVEF |
| 72 |
VTGTLETKYKWCEYG |
| 74 |
GTLETKYKWCEYGLT |
Function
Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (By similarity). The channel adopts an open conformation at zero mV and a closed conformation at both positive and negative potentials (By similarity). There are two populations of channels; the main that functions in a lower open-state conductance with lower ion selectivity, that switch, in a voltage-dependent manner, from the open to a low-conducting 'closed' state and the other that has a normal ion selectivity in the typical high conductance, 'open' state (By similarity). Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol (By similarity). Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway (By similarity). Associates with the translocase of the outer mitochondrial membrane (TOM) complex and PINK1 kinase at depolarized mitochondria, this interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy by the recruitment of the E3 ubiquitin ligase PRKN (By similarity)
Protein Sequence
10
MASYGQTCPR
20
PMCIPPSYAD
30
LGKAARDIFN
40
KGFGFGLVKL
50
DVKTKSCSGV
60
EFSTSGSSNT
70
DTGKVTGTLE
80
TKYKWCEYGL
90
TFTEKWNTDN
100
TLGTEIAIED
110
QICQGLKLTF
120
DTTFSPNTGK
130
KSGKIKSSYK
140
RECVNLGCDV
150
DFDFAGPAIH
160
GSAVFGYEGW
170
LAGYQMTFDS
180
AKSKLTRNNF
190
AVGYRTGDFQ
200
LHTNVNDGTE
210
FGGSIYQKVC
220
EDLDTSVNLA
230
WTSGTNCTRF
240
GIAAKYQLDP
250
TASISAKVNN
260
SSLIGVGYTQ
270
TLRPGVKLTL
280
SALVDGKSIN
290
AGGHKLGLAL
ELEA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005741 |
mitochondrial outer membrane |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Cellular Component |
GO:0046930 |
pore complex |
| Cellular Component |
GO:0097225 |
sperm midpiece |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0097001 |
ceramide binding |
| Molecular Function |
GO:0015485 |
cholesterol binding |
| Molecular Function |
GO:0008142 |
oxysterol binding |
| Molecular Function |
GO:0031210 |
phosphatidylcholine binding |
| Molecular Function |
GO:0015288 |
porin activity |
| Molecular Function |
GO:0008308 |
voltage-gated monoatomic anion channel activity |
| Molecular Function |
GO:0005244 |
voltage-gated monoatomic ion channel activity |
| Biological Process |
GO:0006869 |
lipid transport |
| Biological Process |
GO:0097345 |
mitochondrial outer membrane permeabilization |
| Biological Process |
GO:0006820 |
monoatomic anion transport |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.