Overview
| Uniprot ID | Q9MZ16 |
|---|
| Protein Name | Non-selective voltage-gated ion channel VDAC1 |
|---|
| Gene Name | VDAC1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 109 |
SFSPNTGKKNAKIKT |
| 12 |
PTYADLGKSARDVFT |
| 201 |
IYQKVNKKLETAVNL |
| 266 |
LSALLDGKNVNAGGH |
| 34 |
IKLDLKTKSENGLEF |
| 61 |
VTGSLETKYRWTEYG |
Function
Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol. In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis. May mediate ATP export from cells (By similarity). Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix (By similarity). Mediates cytochrome c efflux (By similarity)
Protein Sequence
10
MAVPPTYADL
20
GKSARDVFTK
30
GYGFGLIKLD
40
LKTKSENGLE
50
FTSSGSANTE
60
TTKVTGSLET
70
KYRWTEYGLT
80
FTEKWNTDNT
90
LGTEITVEDQ
100
LARGLKLTFD
110
SSFSPNTGKK
120
NAKIKTGYKR
130
EHVNLGCDVD
140
FDIAGPSIRG
150
ALVLGYEGWL
160
AGYQMNFETA
170
KSRVTQSNFA
180
VGYKTDEFQL
190
HTNVNDGTEF
200
GGSIYQKVNK
210
KLETAVNLAW
220
TAGNSNTRFG
230
IAAKYQIDPD
240
ACFSAKVNNS
250
SLIGLGYTQT
260
LKPGIKLTLS
270
ALLDGKNVNA
280
GGHKLGLGLE
FQA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0045121 |
membrane raft |
| Cellular Component |
GO:0005741 |
mitochondrial outer membrane |
| Cellular Component |
GO:0005757 |
mitochondrial permeability transition pore complex |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0008142 |
oxysterol binding |
| Molecular Function |
GO:0015288 |
porin activity |
| Molecular Function |
GO:0022832 |
voltage-gated channel activity |
| Molecular Function |
GO:0008308 |
voltage-gated monoatomic anion channel activity |
| Molecular Function |
GO:0005244 |
voltage-gated monoatomic ion channel activity |
| Biological Process |
GO:0006915 |
apoptotic process |
| Biological Process |
GO:0036444 |
calcium import into the mitochondrion |
| Biological Process |
GO:0006869 |
lipid transport |
| Biological Process |
GO:0006820 |
monoatomic anion transport |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.