Overview
| Uniprot ID | Q9N0F1 |
|---|
| Protein Name | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial |
|---|
| Gene Name | DLST |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 205 |
SKPVSAVKPTAAPPV |
| 269 |
QDMRARHKEAFLKKH |
| 355 |
TISELGEKARKNELA |
| 442 |
VTFLRKIKAAVEDPR |
| 68 |
FRTTAVCKDDVITVK |
Function
Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex (PubMed:10806400). The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) (PubMed:10806400). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (By similarity). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (By similarity)
Protein Sequence
10
MLSRSRCVSR
20
AFSRSLSAFQ
30
KGNCPLGRRS
40
LPGISLCQGP
50
GYPDSRKIVI
60
SNSSVLNVRF
70
FRTTAVCKDD
80
VITVKTPAFA
90
ESVTEGDVRW
100
EKAVGDTVAE
110
DEVVCEIETD
120
KTSVQVPSPA
130
NGVIEALLVP
140
DGGKVEGGTP
150
LFTLRKTGAA
160
PAKAKPAEAP
170
AAAAPKAEPA
180
VSAVPPPPAA
190
SIPTQMPPVP
200
SPPQPLTSKP
210
VSAVKPTAAP
220
PVAEPGAVKG
230
LRAEHREKMN
240
RMRQRIAQRL
250
KEAQNTCAML
260
TTFNEIDMSN
270
IQDMRARHKE
280
AFLKKHNLKL
290
GFMSAFVKAS
300
AFALQEQPVV
310
NAVIDDTTKE
320
VVYRDYIDIS
330
VAVATPRGLV
340
VPVIRNVETM
350
NYADIERTIS
360
ELGEKARKNE
370
LAIEDMDGGT
380
FTISNGGVFG
390
SLFGTPIINP
400
PQSAILGMHA
410
IVDRPVAVGG
420
KVEIRPMMYV
430
ALTYDHRLID
440
GREAVTFLRK
450
IKAAVEDPRV
LLLDL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005759 |
mitochondrial matrix |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0045252 |
oxoglutarate dehydrogenase complex |
| Molecular Function |
GO:0004149 |
dihydrolipoyllysine-residue succinyltransferase activity |
| Biological Process |
GO:0006103 |
2-oxoglutarate metabolic process |
| Biological Process |
GO:0033512 |
L-lysine catabolic process to acetyl-CoA via L-saccharopine |
| Biological Process |
GO:0006104 |
succinyl-CoA metabolic process |
| Biological Process |
GO:0006099 |
tricarboxylic acid cycle |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.