Search Results
Overview
| Uniprot ID | Q9NNW7 |
|---|---|
| Protein Name | Thioredoxin reductase 2, mitochondrial |
| Gene Name | TXNRD2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 172 | HTVCGVAKGGKEILL |
| 175 | CGVAKGGKEILLSAD |
| 329 | TRSLNLEKAGVDTSP |
| 506 | TCSEEVVKLRISKRS |
Function
Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis (PubMed:24601690). Maintains thioredoxin in a reduced state. May play a role in redox-regulated cell signaling
Protein Sequence
10
MAAMAVALRG
20
LGGRFRWRTQ
30
AVAGGVRGAA
40
RGAAAGQRDY
50
DLLVVGGGSG
60
GLACAKEAAQ
70
LGRKVAVVDY
80
VEPSPQGTRW
90
GLGGTCVNVG
100
CIPKKLMHQA
110
ALLGGLIQDA
120
PNYGWEVAQP
130
VPHDWRKMAE
140
AVQNHVKSLN
150
WGHRVQLQDR
160
KVKYFNIKAS
170
FVDEHTVCGV
180
AKGGKEILLS
190
ADHIIIATGG
200
RPRYPTHIEG
210
ALEYGITSDD
220
IFWLKESPGK
230
TLVVGASYVA
240
LECAGFLTGI
250
GLDTTIMMRS
260
IPLRGFDQQM
270
SSMVIEHMAS
280
HGTRFLRGCA
290
PSRVRRLPDG
300
QLQVTWEDST
310
TGKEDTGTFD
320
TVLWAIGRVP
330
DTRSLNLEKA
340
GVDTSPDTQK
350
ILVDSREATS
360
VPHIYAIGDV
370
VEGRPELTPI
380
AIMAGRLLVQ
390
RLFGGSSDLM
400
DYDNVPTTVF
410
TPLEYGCVGL
420
SEEEAVARHG
430
QEHVEVYHAH
440
YKPLEFTVAG
450
RDASQCYVKM
460
VCLREPPQLV
470
LGLHFLGPNA
480
GEVTQGFALG
490
IKCGASYAQV
500
MRTVGIHPTC
510
SEEVVKLRIS
520
KRSGLDPTVT
GCUG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0043025 | neuronal cell body |
| Molecular Function | GO:0050660 | flavin adenine dinucleotide binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0004791 | thioredoxin-disulfide reductase (NADPH) activity |
| Biological Process | GO:0045454 | cell redox homeostasis |
| Biological Process | GO:0055093 | response to hyperoxia |
| Biological Process | GO:0000305 | response to oxygen radical |
| Biological Process | GO:0010269 | response to selenium ion |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.