Search Results

Overview

Uniprot IDQ9NP50
Protein NameSIN3-HDAC complex-associated factor
Gene NameSINHCAF
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
104 TLSGNRIKSNQISKL
110 IKSNQISKLQKEFKR
113 NQISKLQKEFKRHNS
72 KLPAGSKKNWNHVVD
87 ARAGPSLKTTLKPKK
96 TLKPKKVKTLSGNRI

Function

Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this subunit is important for the repression of genes encoding components of the TGF-beta signaling pathway (PubMed:22865885, PubMed:22984288). Core component of a SIN3A complex (composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1) present in embryonic stem (ES) cells. Promotes the stability of SIN3A and its presence on chromatin and is essential for maintaining the potential of ES cells to proliferate rapidly, while ensuring a short G1-phase of the cell cycle, thereby preventing premature lineage priming (By similarity)

Protein Sequence

10 MFGFHKPKMY 20 RSIEGCCICR 30 AKSSSSRFTD 40 SKRYEKDFQS 50 CFGLHETRSG 60 DICNACVLLV 70 KRWKKLPAGS 80 KKNWNHVVDA 90 RAGPSLKTTL 100 KPKKVKTLSG 110 NRIKSNQISK 120 LQKEFKRHNS 130 DAHSTTSSAS 140 PAQSPCYSNQ 150 SDDGSDTEMA 160 SGSNRTPVFS 170 FLDLTYWKRQ 180 KICCGIIYKG 190 RFGEVLIDTH 200 LFKPCCSNKK 210 AAAEKPEEQG 220 PEPLPISTQE W

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005634 nucleus
Cellular Component GO:0070822 Sin3-type complex
Biological Process GO:0045596 negative regulation of cell differentiation
Biological Process GO:0030336 negative regulation of cell migration
Biological Process GO:1902455 negative regulation of stem cell population maintenance
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:1902459 positive regulation of stem cell population maintenance

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.