Search Results

Overview

Uniprot ID	Q9NP79
Protein Name	Vacuolar protein sorting-associated protein VTA1 homolog
Gene Name	VTA1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
52	TGMKIDSKTPECRKF

Function

Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity). Involved in HIV-1 budding

Protein Sequence

10 MAALAPLPPL 20 PAQFKSIQHH 30 LRTAQEHDKR 40 DPVVAYYCRL 50 YAMQTGMKID 60 SKTPECRKFL 70 SKLMDQLEAL 80 KKQLGDNEAI 90 TQEIVGCAHL 100 ENYALKMFLY 110 ADNEDRAGRF 120 HKNMIKSFYT 130 ASLLIDVITV 140 FGELTDENVK 150 HRKYARWKAT 160 YIHNCLKNGE 170 TPQAGPVGIE 180 EDNDIEENED 190 AGAASLPTQP 200 TQPSSSSTYD 210 PSNMPSGNYT 220 GIQIPPGAHA 230 PANTPAEVPH 240 STGVASNTIQ 250 PTPQTIPAID 260 PALFNTISQG 270 DVRLTPEDFA 280 RAQKYCKYAG 290 SALQYEDVST 300 AVQNLQKALK LLTTGRE

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0010008	endosome membrane
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005771	multivesicular body
Biological Process	GO:1904903	ESCRT III complex disassembly
Biological Process	GO:0032511	late endosome to vacuole transport via multivesicular body sorting pathway
Biological Process	GO:0016236	macroautophagy
Biological Process	GO:0036258	multivesicular body assembly
Biological Process	GO:0071985	multivesicular body sorting pathway
Biological Process	GO:0015031	protein transport

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.