Search Results
Overview
| Uniprot ID | Q9NP81 |
|---|---|
| Protein Name | Serine--tRNA ligase, mitochondrial |
| Gene Name | SARS2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 147 | ARGREIRKELVHLYP |
Function
Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Protein Sequence
10
MAASMARRLW
20
PLLTRRGFRP
30
RGGCISNDSP
40
RRSFTTEKRN
50
RNLLYEYARE
60
GYSALPQLDI
70
ERFCACPEEA
80
AHALELRKGE
90
LRSADLPAII
100
STWQELRQLQ
110
EQIRSLEEEK
120
AAVTEAVRAL
130
LANQDSGEVQ
140
QDPKYQGLRA
150
RGREIRKELV
160
HLYPREAQLE
170
EQFYLQALKL
180
PNQTHPDVPV
190
GDESQARVLH
200
MVGDKPVFSF
210
QPRGHLEIGE
220
KLDIIRQKRL
230
SHVSGHRSYY
240
LRGAGALLQH
250
GLVNFTFNKL
260
LRRGFTPMTV
270
PDLLRGAVFE
280
GCGMTPNANP
290
SQIYNIDPAR
300
FKDLNLAGTA
310
EVGLAGYFMD
320
HTVAFRDLPV
330
RMVCSSTCYR
340
AETNTGQEPR
350
GLYRVHHFTK
360
VEMFGVTGPG
370
LEQSSQLLEE
380
FLSLQMEILT
390
ELGLHFRVLD
400
MPTQELGLPA
410
YRKFDIEAWM
420
PGRGRFGEVT
430
SASNCTDFQS
440
RRLHIMFQTE
450
AGELQFAHTV
460
NATACAVPRL
470
LIALLESNQQ
480
KDGSVLVPPA
490
LQSYLGTDRI
500
TAPTHVPLQY
510
IGPNQPRKPG
LPGQPAVS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0004828 | serine-tRNA ligase activity |
| Molecular Function | GO:0000049 | tRNA binding |
| Biological Process | GO:0070158 | mitochondrial seryl-tRNA aminoacylation |
| Biological Process | GO:0006434 | seryl-tRNA aminoacylation |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.