Search Results

Overview

Uniprot ID	Q9NPB8
Protein Name	Glycerophosphocholine phosphodiesterase GPCPD1
Gene Name	GPCPD1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
631	VEQLERLKQELPELK

Function

Shows strong preference for glycerophosphocholine. Displays weak activity toward glycerophosphoethanolamine and no detectable activity toward glycerophosphoglycerol, glycerophosphoserine, or glycerophosphoinosito. May be involved in the negative regulation of skeletal muscle differentiation, independently of its glycerophosphocholine phosphodiesterase activity

Protein Sequence

10 MTPSQVAFEI 20 RGTLLPGEVF 30 AICGSCDALG 40 NWNPQNAVAL 50 LPENDTGESM 60 LWKATIVLSR 70 GVSVQYRYFK 80 GYFLEPKTIG 90 GPCQVIVHKW 100 ETHLQPRSIT 110 PLESEIIIDD 120 GQFGIHNGVE 130 TLDSGWLTCQ 140 TEIRLRLHYS 150 EKPPVSITKK 160 KLKKSRFRVK 170 LTLEGLEEDD 180 DDRVSPTVLH 190 KMSNSLEISL 200 ISDNEFKCRH 210 SQPECGYGLQ 220 PDRWTEYSIQ 230 TMEPDNLELI 240 FDFFEEDLSE 250 HVVQGDALPG 260 HVGTACLLSS 270 TIAESGKSAG 280 ILTLPIMSRN 290 SRKTIGKVRV 300 DYIIIKPLPG 310 YSCDMKSSFS 320 KYWKPRIPLD 330 VGHRGAGNST 340 TTAQLAKVQE 350 NTIASLRNAA 360 SHGAAFVEFD 370 VHLSKDFVPV 380 VYHDLTCCLT 390 MKKKFDADPV 400 ELFEIPVKEL 410 TFDQLQLLKL 420 THVTALKSKD 430 RKESVVQEEN 440 SFSENQPFPS 450 LKMVLESLPE 460 DVGFNIEIKW 470 ICQQRDGMWD 480 GNLSTYFDMN 490 LFLDIILKTV 500 LENSGKRRIV 510 FSSFDADICT 520 MVRQKQNKYP 530 ILFLTQGKSE 540 IYPELMDLRS 550 RTTPIAMSFA 560 QFENLLGINV 570 HTEDLLRNPS 580 YIQEAKAKGL 590 VIFCWGDDTN 600 DPENRRKLKE 610 LGVNGLIYDR 620 IYDWMPEQPN 630 IFQVEQLERL 640 KQELPELKSC 650 LCPTVSRFVP 660 SSLCGESDIH 670 VDANGIDNVE NA

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Molecular Function	GO:0047389	glycerophosphocholine phosphodiesterase activity
Molecular Function	GO:2001070	starch binding
Biological Process	GO:0046475	glycerophospholipid catabolic process

Reference

[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.