Overview
| Uniprot ID | Q9NPD5 |
|---|
| Protein Name | Solute carrier organic anion transporter family member 1B3 |
|---|
| Gene Name | SLCO1B3 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 316 |
ANLTNQGKNVTKNVT |
Function
Mediates the Na(+)-independent uptake of organic anions (PubMed:10779507, PubMed:15159445, PubMed:17412826). Shows broad substrate specificity, can transport both organic anions such as bile acid taurocholate (cholyltaurine) and conjugated steroids (17-beta-glucuronosyl estradiol, dehydroepiandrosterone sulfate (DHEAS), and estrone 3-sulfate), as well as eicosanoid leukotriene C4, prostaglandin E2 and L-thyroxine (T4) (PubMed:10779507, PubMed:11159893, PubMed:12568656, PubMed:15159445, PubMed:17412826, PubMed:19129463). Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions (PubMed:19129463). Shows a pH-sensitive substrate specificity towards sulfated steroids, taurocholate and T4 which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (PubMed:19129463). Involved in the clearance of bile acids and organic anions from the liver (PubMed:22232210). Can take up bilirubin glucuronides from plasma into the liver, contributing to the detoxification-enhancing liver-blood shuttling loop (PubMed:22232210). Transports coproporphyrin I and III, by-products of heme synthesis, and may be involved in their hepatic disposition (PubMed:26383540). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Can transport HMG-CoA reductase inhibitors (also known as statins) such as pitavastatin, a clinically important class of hypolipidemic drugs (PubMed:15159445). May play an important role in plasma and tissue distribution of the structurally diverse chemotherapeutic drugs methotrexate and paclitaxel (PubMed:23243220). May also transport antihypertension agents, such as the angiotensin-converting enzyme (ACE) inhibitor prodrug enalapril, and the highly selective angiotensin II AT1-receptor antagonist valsartan, in the liver (PubMed:16624871, PubMed:16627748)
Protein Sequence
10
MDQHQHLNKT
20
AESASSEKKK
30
TRRCNGFKMF
40
LAALSFSYIA
50
KALGGIIMKI
60
SITQIERRFD
70
ISSSLAGLID
80
GSFEIGNLLV
90
IVFVSYFGSK
100
LHRPKLIGIG
110
CLLMGTGSIL
120
TSLPHFFMGY
130
YRYSKETHIN
140
PSENSTSSLS
150
TCLINQTLSF
160
NGTSPEIVEK
170
DCVKESGSHM
180
WIYVFMGNML
190
RGIGETPIVP
200
LGISYIDDFA
210
KEGHSSLYLG
220
SLNAIGMIGP
230
VIGFALGSLF
240
AKMYVDIGYV
250
DLSTIRITPK
260
DSRWVGAWWL
270
GFLVSGLFSI
280
ISSIPFFFLP
290
KNPNKPQKER
300
KISLSLHVLK
310
TNDDRNQTAN
320
LTNQGKNVTK
330
NVTGFFQSLK
340
SILTNPLYVI
350
FLLLTLLQVS
360
SFIGSFTYVF
370
KYMEQQYGQS
380
ASHANFLLGI
390
ITIPTVATGM
400
FLGGFIIKKF
410
KLSLVGIAKF
420
SFLTSMISFL
430
FQLLYFPLIC
440
ESKSVAGLTL
450
TYDGNNSVAS
460
HVDVPLSYCN
470
SECNCDESQW
480
EPVCGNNGIT
490
YLSPCLAGCK
500
SSSGIKKHTV
510
FYNCSCVEVT
520
GLQNRNYSAH
530
LGECPRDNTC
540
TRKFFIYVAI
550
QVINSLFSAT
560
GGTTFILLTV
570
KIVQPELKAL
580
AMGFQSMVIR
590
TLGGILAPIY
600
FGALIDKTCM
610
KWSTNSCGAQ
620
GACRIYNSVF
630
FGRVYLGLSI
640
ALRFPALVLY
650
IVFIFAMKKK
660
FQGKDTKASD
670
NERKVMDEAN
680
LEFLNNGEHF
690
VPSAGTDSKT
700
CNLDMQDNAA
AN
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0009925 |
basal plasma membrane |
| Cellular Component |
GO:0016323 |
basolateral plasma membrane |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0015125 |
bile acid transmembrane transporter activity |
| Molecular Function |
GO:0015291 |
secondary active transmembrane transporter activity |
| Molecular Function |
GO:0004867 |
serine-type endopeptidase inhibitor activity |
| Molecular Function |
GO:0022857 |
transmembrane transporter activity |
| Biological Process |
GO:0015721 |
bile acid and bile salt transport |
| Biological Process |
GO:0042167 |
heme catabolic process |
| Biological Process |
GO:0006811 |
monoatomic ion transport |
| Biological Process |
GO:0015711 |
organic anion transport |
| Biological Process |
GO:0043252 |
sodium-independent organic anion transport |
| Biological Process |
GO:0006805 |
xenobiotic metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.