Overview
| Uniprot ID | Q9NPF5 |
|---|
| Protein Name | DNA methyltransferase 1-associated protein 1 |
|---|
| Gene Name | DMAP1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 27 |
AASGTISKKDIINPD |
| 28 |
ASGTISKKDIINPDK |
Function
Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity
Protein Sequence
10
MATGADVRDI
20
LELGGPEGDA
30
ASGTISKKDI
40
INPDKKKSKK
50
SSETLTFKRP
60
EGMHREVYAL
70
LYSDKKDAPP
80
LLPSDTGQGY
90
RTVKAKLGSK
100
KVRPWKWMPF
110
TNPARKDGAM
120
FFHWRRAAEE
130
GKDYPFARFN
140
KTVQVPVYSE
150
QEYQLYLHDD
160
AWTKAETDHL
170
FDLSRRFDLR
180
FVVIHDRYDH
190
QQFKKRSVED
200
LKERYYHICA
210
KLANVRAVPG
220
TDLKIPVFDA
230
GHERRRKEQL
240
ERLYNRTPEQ
250
VAEEEYLLQE
260
LRKIEARKKE
270
REKRSQDLQK
280
LITAADTTAE
290
QRRTERKAPK
300
KKLPQKKEAE
310
KPAVPETAGI
320
KFPDFKSAGV
330
TLRSQRMKLP
340
SSVGQKKIKA
350
LEQMLLELGV
360
ELSPTPTEEL
370
VHMFNELRSD
380
LVLLYELKQA
390
CANCEYELQM
400
LRHRHEALAR
410
AGVLGGPATP
420
ASGPGPASAE
430
PAVTEPGLGP
440
DPKDTIIDVV
450
GAPLTPNSRK
460
RRESASSSSS
VKKAKKP
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0035267 |
NuA4 histone acetyltransferase complex |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005657 |
replication fork |
| Cellular Component |
GO:0000812 |
Swr1 complex |
| Molecular Function |
GO:0061629 |
RNA polymerase II-specific DNA-binding transcription factor binding |
| Molecular Function |
GO:0003714 |
transcription corepressor activity |
| Biological Process |
GO:0006338 |
chromatin remodeling |
| Biological Process |
GO:0006281 |
DNA repair |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0045892 |
negative regulation of DNA-templated transcription |
| Biological Process |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0045893 |
positive regulation of DNA-templated transcription |
| Biological Process |
GO:1905168 |
positive regulation of double-strand break repair via homologous recombination |
| Biological Process |
GO:0042307 |
positive regulation of protein import into nucleus |
| Biological Process |
GO:0042981 |
regulation of apoptotic process |
| Biological Process |
GO:0051726 |
regulation of cell cycle |
| Biological Process |
GO:0006355 |
regulation of DNA-templated transcription |
| Biological Process |
GO:2000779 |
regulation of double-strand break repair |
| Biological Process |
GO:0045471 |
response to ethanol |
Reference
PMID: N/A