Search Results
Overview
| Uniprot ID | Q9NPH2 |
|---|---|
| Protein Name | Inositol-3-phosphate synthase 1 |
| Gene Name | ISYNA1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 530 | ATYPMLNKKGPVPAA |
| 531 | TYPMLNKKGPVPAAT |
Function
Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner (PubMed:15024000, PubMed:23902760). Rate-limiting enzyme in the synthesis of all inositol-containing compounds (PubMed:15024000)
Protein Sequence
10
MEAAAQFFVE
20
SPDVVYGPEA
30
IEAQYEYRTT
40
RVSREGGVLK
50
VHPTSTRFTF
60
RTARQVPRLG
70
VMLVGWGGNN
80
GSTLTAAVLA
90
NRLRLSWPTR
100
SGRKEANYYG
110
SLTQAGTVSL
120
GLDAEGQEVF
130
VPFSAVLPMV
140
APNDLVFDGW
150
DISSLNLAEA
160
MRRAKVLDWG
170
LQEQLWPHME
180
ALRPRPSVYI
190
PEFIAANQSA
200
RADNLIPGSR
210
AQQLEQIRRD
220
IRDFRSSAGL
230
DKVIVLWTAN
240
TERFCEVIPG
250
LNDTAENLLR
260
TIELGLEVSP
270
STLFAVASIL
280
EGCAFLNGSP
290
QNTLVPGALE
300
LAWQHRVFVG
310
GDDFKSGQTK
320
VKSVLVDFLI
330
GSGLKTMSIV
340
SYNHLGNNDG
350
ENLSAPLQFR
360
SKEVSKSNVV
370
DDMVQSNPVL
380
YTPGEEPDHC
390
VVIKYVPYVG
400
DSKRALDEYT
410
SELMLGGTNT
420
LVLHNTCEDS
430
LLAAPIMLDL
440
ALLTELCQRV
450
SFCTDMDPEP
460
QTFHPVLSLL
470
SFLFKAPLVP
480
PGSPVVNALF
490
RQRSCIENIL
500
RACVGLPPQN
510
HMLLEHKMER
520
PGPSLKRVGP
530
VAATYPMLNK
540
KGPVPAATNG
550
CTGDANGHLQ
EEPPMPTT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0004512 | inositol-3-phosphate synthase activity |
| Biological Process | GO:0006021 | inositol biosynthetic process |
| Biological Process | GO:0008654 | phospholipid biosynthetic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.