Search Results

Overview

Uniprot IDQ9NPJ3
Protein NameAcyl-coenzyme A thioesterase 13
Gene NameACOT13
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
108 VITAHVLKQGKTLAF
111 AHVLKQGKTLAFTSV
123 TSVDLTNKATGKLIA
127 LTNKATGKLIAQGRH
13 QSLREVIKAMTKARN
27 NFERVLGKITLVSAA
37 LVSAAPGKVICEMKV

Function

Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:16934754, PubMed:19170545). Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates (By similarity) (PubMed:16934754, PubMed:19170545). Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro) (By similarity) (PubMed:16934754, PubMed:19170545). May play a role in controlling adaptive thermogenesis (By similarity)

Protein Sequence

10 MTSMTQSLRE 20 VIKAMTKARN 30 FERVLGKITL 40 VSAAPGKVIC 50 EMKVEEEHTN 60 AIGTLHGGLT 70 ATLVDNISTM 80 ALLCTERGAP 90 GVSVDMNITY 100 MSPAKLGEDI 110 VITAHVLKQG 120 KTLAFTSVDL 130 TNKATGKLIA 140 QGRHTKHLGN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005819 spindle
Molecular Function GO:0047617 fatty acyl-CoA hydrolase activity
Molecular Function GO:0046872 metal ion binding
Biological Process GO:0006629 lipid metabolic process
Biological Process GO:0120163 negative regulation of cold-induced thermogenesis
Biological Process GO:0051289 protein homotetramerization

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.