Search Results
Overview
| Uniprot ID | Q9NQ94 |
|---|---|
| Protein Name | APOBEC1 complementation factor |
| Gene Name | A1CF |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 6 | **MESNHKSGDGLSG |
Function
Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay
Protein Sequence
10
MESNHKSGDG
20
LSGTQKEAAL
30
RALVQRTGYS
40
LVQENGQRKY
50
GGPPPGWDAA
60
PPERGCEIFI
70
GKLPRDLFED
80
ELIPLCEKIG
90
KIYEMRMMMD
100
FNGNNRGYAF
110
VTFSNKVEAK
120
NAIKQLNNYE
130
IRNGRLLGVC
140
ASVDNCRLFV
150
GGIPKTKKRE
160
EILSEMKKVT
170
EGVVDVIVYP
180
SAADKTKNRG
190
FAFVEYESHR
200
AAAMARRKLL
210
PGRIQLWGHG
220
IAVDWAEPEV
230
EVDEDTMSSV
240
KILYVRNLML
250
STSEEMIEKE
260
FNNIKPGAVE
270
RVKKIRDYAF
280
VHFSNREDAV
290
EAMKALNGKV
300
LDGSPIEVTL
310
AKPVDKDSYV
320
RYTRGTGGRG
330
TMLQGEYTYS
340
LGQVYDPTTT
350
YLGAPVFYAP
360
QTYAAIPSLH
370
FPATKGHLSN
380
RAIIRAPSVR
390
EIYMNVPVGA
400
AGVRGLGGRG
410
YLAYTGLGRG
420
YQVKGDKRED
430
KLYDILPGME
440
LTPMNPVTLK
450
PQGIKLAPQI
460
LEEICQKNNW
470
GQPVYQLHSA
480
IGQDQRQLFL
490
YKITIPALAS
500
QNPAIHPFTP
510
PKLSAFVDEA
520
KTYAAEYTLQ
530
TLGIPTDGGD
540
GTMATAAAAA
550
TAFPGYAVPN
560
ATAPVSAAQL
570
KQAVTLGQDL
580
AAYTTYEVYP
590
TFAVTARGDG
YGTF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030895 | apolipoprotein B mRNA editing enzyme complex |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0140767 | enzyme-substrate adaptor activity |
| Molecular Function | GO:0003729 | mRNA binding |
| Molecular Function | GO:0003727 | single-stranded RNA binding |
| Biological Process | GO:0141166 | chromosomal 5-methylcytosine DNA demethylation pathway |
| Biological Process | GO:0016554 | cytidine to uridine editing |
| Biological Process | GO:0016556 | mRNA modification |
| Biological Process | GO:0006397 | mRNA processing |
| Biological Process | GO:2000623 | negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| Biological Process | GO:0050821 | protein stabilization |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.