Search Results
Overview
| Uniprot ID | Q9NQC1 |
|---|---|
| Protein Name | E3 ubiquitin-protein ligase Jade-2 |
| Gene Name | JADE2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 7 | *MEEKRRKYSISSDN |
Function
Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653). Acts as an E3 ubiquitin-protein ligase mediating the ubiquitination and subsequent proteasomal degradation of target protein histone demethylase KDM1A (PubMed:25018020). Also acts as a ubiquitin ligase E3 toward itself. Positive regulator of neurogenesis (By similarity)
Protein Sequence
10
MEEKRRKYSI
20
SSDNSDTTDS
30
HATSTSASRC
40
SKLPSSTKSG
50
WPRQNEKKPS
60
EVFRTDLITA
70
MKIPDSYQLS
80
PDDYYILADP
90
WRQEWEKGVQ
100
VPAGAEAIPE
110
PVVRILPPLE
120
GPPAQASPSS
130
TMLGEGSQPD
140
WPGGSRYDLD
150
EIDAYWLELI
160
NSELKEMERP
170
ELDELTLERV
180
LEELETLCHQ
190
NMARAIETQE
200
GLGIEYDEDV
210
VCDVCRSPEG
220
EDGNEMVFCD
230
KCNVCVHQAC
240
YGILKVPTGS
250
WLCRTCALGV
260
QPKCLLCPKR
270
GGALKPTRSG
280
TKWVHVSCAL
290
WIPEVSIGCP
300
EKMEPITKIS
310
HIPASRWALS
320
CSLCKECTGT
330
CIQCSMPSCV
340
TAFHVTCAFD
350
HGLEMRTILA
360
DNDEVKFKSF
370
CQEHSDGGPR
380
NEPTSEPTEP
390
SQAGEDLEKV
400
TLRKQRLQQL
410
EEDFYELVEP
420
AEVAERLDLA
430
EALVDFIYQY
440
WKLKRKANAN
450
QPLLTPKTDE
460
VDNLAQQEQD
470
VLYRRLKLFT
480
HLRQDLERVR
490
NLCYMVTRRE
500
RTKHAICKLQ
510
EQIFHLQMKL
520
IEQDLCRGLS
530
TSFPIDGTFF
540
NSWLAQSVQI
550
TAENMAMSEW
560
PLNNGHREDP
570
APGLLSEELL
580
QDEETLLSFM
590
RDPSLRPGDP
600
ARKARGRTRL
610
PAKKKPPPPP
620
PQDGPGSRTT
630
PDKAPKKTWG
640
QDAGSGKGGQ
650
GPPTRKPPRR
660
TSSHLPSSPA
670
AGDCPILATP
680
ESPPPLAPET
690
PDEAASVAAD
700
SDVQVPGPAA
710
SPKPLGRLRP
720
PRESKVTRRL
730
PGARPDAGMG
740
PPSAVAERPK
750
VSLHFDTETD
760
GYFSDGEMSD
770
SDVEAEDGGV
780
QRGPREAGAE
790
EVVRMGVLAS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0000123 | histone acetyltransferase complex |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0043997 | histone H4K12 acetyltransferase activity |
| Molecular Function | GO:0043995 | histone H4K5 acetyltransferase activity |
| Molecular Function | GO:0043996 | histone H4K8 acetyltransferase activity |
| Molecular Function | GO:0140566 | histone reader activity |
| Molecular Function | GO:0061630 | ubiquitin protein ligase activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006338 | chromatin remodeling |
| Biological Process | GO:0016567 | protein ubiquitination |
| Biological Process | GO:0051726 | regulation of cell cycle |
| Biological Process | GO:2000278 | regulation of DNA biosynthetic process |
| Biological Process | GO:0006275 | regulation of DNA replication |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.