Search Results

Overview

Uniprot ID	Q9NQC3
Protein Name	Reticulon-4
Gene Name	RTN4
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1066	GVIQAIQKSDEGHPF
1104	GHVNCTIKELRRLFL
1171	HYLGLANKNVKDAMA
1174	GLANKNVKDAMAKIQ
1183	AMAKIQAKIPGLKRK
281	KEVSEKAKTLLIDRD
884	SKTDSFSKLAREYTD

Function

Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:24262037, PubMed:25612671, PubMed:27619977, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable)

Protein Sequence

10 MEDLDQSPLV 20 SSSDSPPRPQ 30 PAFKYQFVRE 40 PEDEEEEEEE 50 EEEDEDEDLE 60 ELEVLERKPA 70 AGLSAAPVPT 80 APAAGAPLMD 90 FGNDFVPPAP 100 RGPLPAAPPV 110 APERQPSWDP 120 SPVSSTVPAP 130 SPLSAAAVSP 140 SKLPEDDEPP 150 ARPPPPPPAS 160 VSPQAEPVWT 170 PPAPAPAAPP 180 STPAAPKRRG 190 SSGSVDETLF 200 ALPAASEPVI 210 RSSAENMDLK 220 EQPGNTISAG 230 QEDFPSVLLE 240 TAASLPSLSP 250 LSAASFKEHE 260 YLGNLSTVLP 270 TEGTLQENVS 280 EASKEVSEKA 290 KTLLIDRDLT 300 EFSELEYSEM 310 GSSFSVSPKA 320 ESAVIVANPR 330 EEIIVKNKDE 340 EEKLVSNNIL 350 HNQQELPTAL 360 TKLVKEDEVV 370 SSEKAKDSFN 380 EKRVAVEAPM 390 REEYADFKPF 400 ERVWEVKDSK 410 EDSDMLAAGG 420 KIESNLESKV 430 DKKCFADSLE 440 QTNHEKDSES 450 SNDDTSFPST 460 PEGIKDRSGA 470 YITCAPFNPA 480 ATESIATNIF 490 PLLGDPTSEN 500 KTDEKKIEEK 510 KAQIVTEKNT 520 STKTSNPFLV 530 AAQDSETDYV 540 TTDNLTKVTE 550 EVVANMPEGL 560 TPDLVQEACE 570 SELNEVTGTK 580 IAYETKMDLV 590 QTSEVMQESL 600 YPAAQLCPSF 610 EESEATPSPV 620 LPDIVMEAPL 630 NSAVPSAGAS 640 VIQPSSSPLE 650 ASSVNYESIK 660 HEPENPPPYE 670 EAMSVSLKKV 680 SGIKEEIKEP 690 ENINAALQET 700 EAPYISIACD 710 LIKETKLSAE 720 PAPDFSDYSE 730 MAKVEQPVPD 740 HSELVEDSSP 750 DSEPVDLFSD 760 DSIPDVPQKQ 770 DETVMLVKES 780 LTETSFESMI 790 EYENKEKLSA 800 LPPEGGKPYL 810 ESFKLSLDNT 820 KDTLLPDEVS 830 TLSKKEKIPL 840 QMEELSTAVY 850 SNDDLFISKE 860 AQIRETETFS 870 DSSPIEIIDE 880 FPTLISSKTD 890 SFSKLAREYT 900 DLEVSHKSEI 910 ANAPDGAGSL 920 PCTELPHDLS 930 LKNIQPKVEE 940 KISFSDDFSK 950 NGSATSKVLL 960 LPPDVSALAT 970 QAEIESIVKP 980 KVLVKEAEKK 990 LPSDTEKEDR 1000 SPSAIFSAEL 1010 SKTSVVDLLY 1020 WRDIKKTGVV 1030 FGASLFLLLS 1040 LTVFSIVSVT 1050 AYIALALLSV 1060 TISFRIYKGV 1070 IQAIQKSDEG 1080 HPFRAYLESE 1090 VAISEELVQK 1100 YSNSALGHVN 1110 CTIKELRRLF 1120 LVDDLVDSLK 1130 FAVLMWVFTY 1140 VGALFNGLTL 1150 LILALISLFS 1160 VPVIYERHQA 1170 QIDHYLGLAN 1180 KNVKDAMAKI 1190 QAKIPGLKRK AE

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0070161	anchoring junction
Cellular Component	GO:0030054	cell junction
Cellular Component	GO:0005783	endoplasmic reticulum
Cellular Component	GO:0005789	endoplasmic reticulum membrane
Cellular Component	GO:0071782	endoplasmic reticulum tubular network
Cellular Component	GO:0098826	endoplasmic reticulum tubular network membrane
Cellular Component	GO:0098978	glutamatergic synapse
Cellular Component	GO:0043005	neuron projection
Cellular Component	GO:0043025	neuronal cell body
Cellular Component	GO:0005635	nuclear envelope
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0014069	postsynaptic density
Cellular Component	GO:0045202	synapse
Molecular Function	GO:0045296	cadherin binding
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0042803	protein homodimerization activity
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0031625	ubiquitin protein ligase binding
Biological Process	GO:0006915	apoptotic process
Biological Process	GO:0007413	axonal fasciculation
Biological Process	GO:0007420	brain development
Biological Process	GO:0120078	cell adhesion involved in sprouting angiogenesis
Biological Process	GO:0035441	cell migration involved in vasculogenesis
Biological Process	GO:0071456	cellular response to hypoxia
Biological Process	GO:0022009	central nervous system vasculogenesis
Biological Process	GO:0021801	cerebral cortex radial glia-guided migration
Biological Process	GO:0007029	endoplasmic reticulum organization
Biological Process	GO:0071787	endoplasmic reticulum tubular network formation
Biological Process	GO:1990809	endoplasmic reticulum tubular network membrane organization
Biological Process	GO:0071786	endoplasmic reticulum tubular network organization
Biological Process	GO:0090156	intracellular sphingolipid homeostasis
Biological Process	GO:0002523	leukocyte migration involved in inflammatory response
Biological Process	GO:0050804	modulation of chemical synaptic transmission
Biological Process	GO:1902430	negative regulation of amyloid-beta formation
Biological Process	GO:0030517	negative regulation of axon extension
Biological Process	GO:0030308	negative regulation of cell growth
Biological Process	GO:2001213	negative regulation of vasculogenesis
Biological Process	GO:0030182	neuron differentiation
Biological Process	GO:0051292	nuclear pore complex assembly
Biological Process	GO:0045766	positive regulation of angiogenesis
Biological Process	GO:1905653	positive regulation of artery morphogenesis
Biological Process	GO:0010634	positive regulation of epithelial cell migration
Biological Process	GO:1905580	positive regulation of ERBB3 signaling pathway
Biological Process	GO:2000347	positive regulation of hepatocyte proliferation
Biological Process	GO:0060907	positive regulation of macrophage cytokine production
Biological Process	GO:1905523	positive regulation of macrophage migration
Biological Process	GO:0033601	positive regulation of mammary gland epithelial cell proliferation
Biological Process	GO:1902624	positive regulation of neutrophil migration
Biological Process	GO:0051897	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Process	GO:1905552	positive regulation of protein localization to endoplasmic reticulum
Biological Process	GO:0035022	positive regulation of Rac protein signal transduction
Biological Process	GO:0034165	positive regulation of toll-like receptor 9 signaling pathway
Biological Process	GO:0061462	protein localization to lysosome
Biological Process	GO:0050821	protein stabilization
Biological Process	GO:0042981	regulation of apoptotic process
Biological Process	GO:2000172	regulation of branching morphogenesis of a nerve
Biological Process	GO:0030334	regulation of cell migration
Biological Process	GO:0150052	regulation of postsynapse assembly

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.