Overview
| Uniprot ID | Q9NQG5 |
|---|
| Protein Name | Regulation of nuclear pre-mRNA domain-containing protein 1B |
|---|
| Gene Name | RPRD1B |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 73 |
VIQNSKRKGPEFTRE |
Function
Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation
Protein Sequence
10
MSSFSESALE
20
KKLSELSNSQ
30
QSVQTLSLWL
40
IHHRKHAGPI
50
VSVWHRELRK
60
AKSNRKLTFL
70
YLANDVIQNS
80
KRKGPEFTRE
90
FESVLVDAFS
100
HVAREADEGC
110
KKPLERLLNI
120
WQERSVYGGE
130
FIQQLKLSME
140
DSKSPPPKAT
150
EEKKSLKRTF
160
QQIQEEEDDD
170
YPGSYSPQDP
180
SAGPLLTEEL
190
IKALQDLENA
200
ASGDATVRQK
210
IASLPQEVQD
220
VSLLEKITDK
230
EAAERLSKTV
240
DEACLLLAEY
250
NGRLAAELED
260
RRQLARMLVE
270
YTQNQKDVLS
280
EKEKKLEEYK
290
QKLARVTQVR
300
KELKSHIQSL
310
PDLSLLPNVT
320
GGLAPLPSAG
DLFSTD
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0097550 |
transcription preinitiation complex |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0099122 |
RNA polymerase II C-terminal domain binding |
| Molecular Function |
GO:0000993 |
RNA polymerase II complex binding |
| Biological Process |
GO:0031124 |
mRNA 3'-end processing |
| Biological Process |
GO:0008284 |
positive regulation of cell population proliferation |
| Biological Process |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0010564 |
regulation of cell cycle process |
| Biological Process |
GO:0001111 |
RNA polymerase II promoter clearance |
Reference
[1] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.