Search Results
Overview
| Uniprot ID | Q9NQR4 |
|---|---|
| Protein Name | Omega-amidase NIT2 |
| Gene Name | NIT2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 112 | TLLAKYRKIHLFDID |
| 123 | FDIDVPGKITFQESK |
Function
Has omega-amidase activity (PubMed:19595734, PubMed:22674578). The role of omega-amidase is to remove potentially toxic intermediates by converting 2-oxoglutaramate and 2-oxosuccinamate to biologically useful 2-oxoglutarate and oxaloacetate, respectively (PubMed:19595734)
Protein Sequence
10
MTSFRLALIQ
20
LQISSIKSDN
30
VTRACSFIRE
40
AATQGAKIVS
50
LPECFNSPYG
60
AKYFPEYAEK
70
IPGESTQKLS
80
EVAKECSIYL
90
IGGSIPEEDA
100
GKLYNTCAVF
110
GPDGTLLAKY
120
RKIHLFDIDV
130
PGKITFQESK
140
TLSPGDSFST
150
FDTPYCRVGL
160
GICYDMRFAE
170
LAQIYAQRGC
180
QLLVYPGAFN
190
LTTGPAHWEL
200
LQRSRAVDNQ
210
VYVATASPAR
220
DDKASYVAWG
230
HSTVVNPWGE
240
VLAKAGTEEA
250
IVYSDIDLKK
260
LAEIRQQIPV
270
FRQKRSDLYA
VEMKKP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0035580 | specific granule lumen |
| Cellular Component | GO:1904724 | tertiary granule lumen |
| Molecular Function | GO:0106008 | 2-oxoglutaramate amidase activity |
| Molecular Function | GO:0050152 | omega-amidase activity |
| Biological Process | GO:0006528 | asparagine metabolic process |
| Biological Process | GO:0006541 | glutamine metabolic process |
| Biological Process | GO:0006107 | oxaloacetate metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.