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Overview

Uniprot IDQ9NQS7
Protein NameInner centromere protein
Gene NameINCENP
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
487 SSPCPASKVVRPLRT
571 RRRLEEVKLKREERL
631 KKKAAAKKMEEVEAR
916 SSLAYSLKKH*****
917 SLAYSLKKH******

Function

Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428)

Protein Sequence

10 MGTTAPGPIH 20 LLELCDQKLM 30 EFLCNMDNKD 40 LVWLEEIQEE 50 AERMFTREFS 60 KEPELMPKTP 70 SQKNRRKKRR 80 ISYVQDENRD 90 PIRRRLSRRK 100 SRSSQLSSRR 110 LRSKDSVEKL 120 ATVVGENGSV 130 LRRVTRAAAA 140 AAAATMALAA 150 PSSPTPESPT 160 MLTKKPEDNH 170 TQCQLVPVVE 180 IGISERQNAE 190 QHVTQLMSTE 200 PLPRTLSPTP 210 ASATAPTSQG 220 IPTSDEESTP 230 KKSKARILES 240 ITVSSLMATP 250 QDPKGQGVGT 260 GRSASKLRIA 270 QVSPGPRDSP 280 AFPDSPWRER 290 VLAPILPDNF 300 STPTGSRTDS 310 QSVRHSPIAP 320 SSPSPQVLAQ 330 KYSLVAKQES 340 VVRRASRRLA 350 KKTAEEPAAS 360 GRIICHSYLE 370 RLLNVEVPQK 380 VGSEQKEPPE 390 EAEPVAAAEP 400 EVPENNGNNS 410 WPHNDTEIAN 420 STPNPKPAAS 430 SPETPSAGQQ 440 EAKTDQADGP 450 REPPQSARRK 460 RSYKQAVSEL 470 DEEQHLEDEE 480 LQPPRSKTPS 490 SPCPASKVVR 500 PLRTFLHTVQ 510 RNQMLMTPTS 520 APRSVMKSFI 530 KRNTPLRMDP 540 KCSFVEKERQ 550 RLENLRRKEE 560 AEQLRRQKVE 570 EDKRRRLEEV 580 KLKREERLRK 590 VLQARERVEQ 600 MKEEKKKQIE 610 QKFAQIDEKT 620 EKAKEERLAE 630 EKAKKKAAAK 640 KMEEVEARRK 650 QEEEARRLRW 660 LQQEEEERRH 670 QELLQKKKEE 680 EQERLRKAAE 690 AKRLAEQREQ 700 ERREQERREQ 710 ERREQERREQ 720 ERREQERQLA 730 EQERRREQER 740 LQAERELQER 750 EKALRLQKEQ 760 LQRELEEKKK 770 KEEQQRLAER 780 QLQEEQEKKA 790 KEAAGASKAL 800 NVTVDVQSPA 810 CTSYQMTPQG 820 HRAPPKINPD 830 NYGMDLNSDD 840 STDDEAHPRK 850 PIPTWARGTP 860 LSQAIIHQYY 870 HPPNLLELFG 880 TILPLDLEDI 890 FKKSKPRYHK 900 RTSSAVWNSP 910 PLQGARVPSS LAYSLKKH

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000801 central element
Cellular Component GO:0010369 chromocenter
Cellular Component GO:0032133 chromosome passenger complex
Cellular Component GO:0000775 chromosome, centromeric region
Cellular Component GO:0005829 cytosol
Cellular Component GO:0000776 kinetochore
Cellular Component GO:0000800 lateral element
Cellular Component GO:1990385 meiotic spindle midzone
Cellular Component GO:0005874 microtubule
Cellular Component GO:0015630 microtubule cytoskeleton
Cellular Component GO:0030496 midbody
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005721 pericentric heterochromatin
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:0005819 spindle
Molecular Function GO:0140677 molecular function activator activity
Biological Process GO:0007059 chromosome segregation
Biological Process GO:0051257 meiotic spindle midzone assembly
Biological Process GO:0051310 metaphase chromosome alignment
Biological Process GO:0000278 mitotic cell cycle
Biological Process GO:0000281 mitotic cytokinesis
Biological Process GO:0090307 mitotic spindle assembly
Biological Process GO:0051256 mitotic spindle midzone assembly
Biological Process GO:1902425 positive regulation of attachment of mitotic spindle microtubules to kinetochore
Biological Process GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint
Biological Process GO:1903490 positive regulation of mitotic cytokinesis
Biological Process GO:1901970 positive regulation of mitotic sister chromatid separation

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.