Overview
| Uniprot ID | Q9NQT4 |
|---|
| Protein Name | Exosome complex component RRP46 |
|---|
| Gene Name | EXOSC5 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 73 |
VSKEIFNKATLEVIL |
Function
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes (PubMed:11782436, PubMed:21269460). In vitro, EXOSC5 does not bind or digest single-stranded RNA and binds to double-stranded DNA without detectable DNase activity (PubMed:20660080)
Protein Sequence
10
MEEETHTDAK
20
IRAENGTGSS
30
PRGPGCSLRH
40
FACEQNLLSR
50
PDGSASFLQG
60
DTSVLAGVYG
70
PAEVKVSKEI
80
FNKATLEVIL
90
RPKIGLPGVA
100
EKSRERLIRN
110
TCEAVVLGTL
120
HPRTSITVVL
130
QVVSDAGSLL
140
ACCLNAACMA
150
LVDAGVPMRA
160
LFCGVACALD
170
SDGTLVLDPT
180
SKQEKEARAV
190
LTFALDSVER
200
KLLMSSTKGL
210
YSDTELQQCL
220
AAAQAASQHV
230
FRFYRESLQR
RYSKS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0000177 |
cytoplasmic exosome (RNase complex) |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0000791 |
euchromatin |
| Cellular Component |
GO:0000178 |
exosome (RNase complex) |
| Cellular Component |
GO:0000176 |
nuclear exosome (RNase complex) |
| Cellular Component |
GO:0005730 |
nucleolus |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0000175 |
3'-5'-RNA exonuclease activity |
| Molecular Function |
GO:0003677 |
DNA binding |
| Molecular Function |
GO:0003723 |
RNA binding |
| Biological Process |
GO:0051607 |
defense response to virus |
| Biological Process |
GO:0045006 |
DNA deamination |
| Biological Process |
GO:0006402 |
mRNA catabolic process |
| Biological Process |
GO:0071028 |
nuclear mRNA surveillance |
| Biological Process |
GO:0071051 |
poly(A)-dependent snoRNA 3'-end processing |
| Biological Process |
GO:0006401 |
RNA catabolic process |
| Biological Process |
GO:0006396 |
RNA processing |
| Biological Process |
GO:0016075 |
rRNA catabolic process |
| Biological Process |
GO:0006364 |
rRNA processing |
| Biological Process |
GO:0034475 |
U4 snRNA 3'-end processing |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.