Search Results

Overview

Uniprot IDQ9NQW6
Protein NameAnillin
Gene NameANLN
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
143 ATAASSVKTRMQKLA
148 SVKTRMQKLAEQRRR
237 PGTACLSKFSSASGA
335 GVSKPIVKSTLSQTV
345 LSQTVPSKGELSREI
359 ICLQSQSKDKSTTPG
444 CLRGRFDKGNIWSAE
452 GNIWSAEKGGNSKSK
475 HCQSTPLKKHQGVSK
476 CQSTPLKKHQGVSKT
482 KKHQGVSKTQSLPVT
647 DESPKPGKFQRTRVP
690 ETERPSIKQVIVRKE
790 EGPQRKNKASPQSEF
903 KKKTSKSKAITPKRL

Function

Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636)

Protein Sequence

10 MDPFTEKLLE 20 RTRARRENLQ 30 RKMAERPTAA 40 PRSMTHAKRA 50 RQPLSEASNQ 60 QPLSGGEEKS 70 CTKPSPSKKR 80 CSDNTEVEVS 90 NLENKQPVES 100 TSAKSCSPSP 110 VSPQVQPQAA 120 DTISDSVAVP 130 ASLLGMRRGL 140 NSRLEATAAS 150 SVKTRMQKLA 160 EQRRRWDNDD 170 MTDDIPESSL 180 FSPMPSEEKA 190 ASPPRPLLSN 200 ASATPVGRRG 210 RLANLAATIC 220 SWEDDVNHSF 230 AKQNSVQEQP 240 GTACLSKFSS 250 ASGASARINS 260 SSVKQEATFC 270 SQRDGDASLN 280 KALSSSADDA 290 SLVNASISSS 300 VKATSPVKST 310 TSITDAKSCE 320 GQNPELLPKT 330 PISPLKTGVS 340 KPIVKSTLSQ 350 TVPSKGELSR 360 EICLQSQSKD 370 KSTTPGGTGI 380 KPFLERFGER 390 CQEHSKESPA 400 RSTPHRTPII 410 TPNTKAIQER 420 LFKQDTSSST 430 THLAQQLKQE 440 RQKELACLRG 450 RFDKGNIWSA 460 EKGGNSKSKQ 470 LETKQETHCQ 480 STPLKKHQGV 490 SKTQSLPVTE 500 KVTENQIPAK 510 NSSTEPKGFT 520 ECEMTKSSPL 530 KITLFLEEDK 540 SLKVTSDPKV 550 EQKIEVIREI 560 EMSVDDDDIN 570 SSKVINDLFS 580 DVLEEGELDM 590 EKSQEEMDQA 600 LAESSEEQED 610 ALNISSMSLL 620 APLAQTVGVV 630 SPESLVSTPR 640 LELKDTSRSD 650 ESPKPGKFQR 660 TRVPRAESGD 670 SLGSEDRDLL 680 YSIDAYRSQR 690 FKETERPSIK 700 QVIVRKEDVT 710 SKLDEKNNAF 720 PCQVNIKQKM 730 QELNNEINMQ 740 QTVIYQASQA 750 LNCCVDEEHG 760 KGSLEEAEAE 770 RLLLIATGKR 780 TLLIDELNKL 790 KNEGPQRKNK 800 ASPQSEFMPS 810 KGSVTLSEIR 820 LPLKADFVCS 830 TVQKPDAANY 840 YYLIILKAGA 850 ENMVATPLAS 860 TSNSLNGDAL 870 TFTTTFTLQD 880 VSNDFEINIE 890 VYSLVQKKDP 900 SGLDKKKKTS 910 KSKAITPKRL 920 LTSITTKSNI 930 HSSVMASPGG 940 LSAVRTSNFA 950 LVGSYTLSLS 960 SVGNTKFVLD 970 KVPFLSSLEG 980 HIYLKIKCQV 990 NSSVEERGFL 1000 TIFEDVSGFG 1010 AWHRRWCVLS 1020 GNCISYWTYP 1030 DDEKRKNPIG 1040 RINLANCTSR 1050 QIEPANREFC 1060 ARRNTFELIT 1070 VRPQREDDRE 1080 TLVSQCRDTL 1090 CVTKNWLSAD 1100 TKEERDLWMQ 1110 KLNQVLVDIR 1120 LWQPDACYKP IGKP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015629 actin cytoskeleton
Cellular Component GO:0005826 actomyosin contractile ring
Cellular Component GO:0032059 bleb
Cellular Component GO:0005938 cell cortex
Cellular Component GO:0005829 cytosol
Cellular Component GO:0030496 midbody
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0003779 actin binding
Molecular Function GO:0045296 cadherin binding
Biological Process GO:0000915 actomyosin contractile ring assembly
Biological Process GO:0000281 mitotic cytokinesis
Biological Process GO:0090521 podocyte cell migration
Biological Process GO:1904172 positive regulation of bleb assembly
Biological Process GO:0007096 regulation of exit from mitosis
Biological Process GO:0000921 septin ring assembly
Biological Process GO:0031106 septin ring organization

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.