Overview
| Uniprot ID | Q9NQX0 |
|---|
| Protein Name | Putative histone-lysine N-methyltransferase PRDM6 |
|---|
| Gene Name | PRDM6 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 409 |
QPFNKSSKLAPTTQQ |
Function
Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression
Protein Sequence
10
MLKPGDPGGS
20
AFLKVDPAYL
30
QHWQQLFPHG
40
GAGPLKGSGA
50
AGLLSAPQPL
60
QPPPPPPPPE
70
RAEPPPDSLR
80
PRPASLSSAS
90
STPASSSTSA
100
SSASSCAAAA
110
AAAALAGLSA
120
LPVSQLPVFA
130
PLAAAAVAAE
140
PLPPKELCLG
150
ATSGPGPVKC
160
GGGGGGGGEG
170
RGAPRFRCSA
180
EELDYYLYGQ
190
QRMEIIPLNQ
200
HTSDPNNRCD
210
MCADNRNGEC
220
PMHGPLHSLR
230
RLVGTSSAAA
240
AAPPPELPEW
250
LRDLPREVCL
260
CTSTVPGLAY
270
GICAAQRIQQ
280
GTWIGPFQGV
290
LLPPEKVQAG
300
AVRNTQHLWE
310
IYDQDGTLQH
320
FIDGGEPSKS
330
SWMRYIRCAR
340
HCGEQNLTVV
350
QYRSNIFYRA
360
CIDIPRGTEL
370
LVWYNDSYTS
380
FFGIPLQCIA
390
QDENLNVPST
400
VMEAMCRQDA
410
LQPFNKSSKL
420
APTTQQRSVV
430
FPQTPCSRNF
440
SLLDKSGPIE
450
SGFNQINVKN
460
QRVLASPTST
470
SQLHSEFSDW
480
HLWKCGQCFK
490
TFTQRILLQM
500
HVCTQNPDRP
510
YQCGHCSQSF
520
SQPSELRNHV
530
VTHSSDRPFK
540
CGYCGRAFAG
550
ATTLNNHIRT
560
HTGEKPFKCE
570
RCERSFTQAT
580
QLSRHQRMPN
590
ECKPITESPE
SIEVD
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0140944 |
histone H4K20 monomethyltransferase activity |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0008270 |
zinc ion binding |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0032259 |
methylation |
| Biological Process |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0010468 |
regulation of gene expression |
Reference
PMID: N/A