Search Results
Overview
| Uniprot ID | Q9NQX3 |
|---|---|
| Protein Name | Gephyrin |
| Gene Name | GPHN |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 288 | TASCPTPKVQSRCSS |
| 296 | VQSRCSSKENILRAS |
Function
Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Acts as a major instructive molecule at inhibitory synapses, where it also clusters GABA type A receptors (PubMed:25025157, PubMed:26613940)
Protein Sequence
10
MATEGMILTN
20
HDHQIRVGVL
30
TVSDSCFRNL
40
AEDRSGINLK
50
DLVQDPSLLG
60
GTISAYKIVP
70
DEIEEIKETL
80
IDWCDEKELN
90
LILTTGGTGF
100
APRDVTPEAT
110
KEVIEREAPG
120
MALAMLMGSL
130
NVTPLGMLSR
140
PVCGIRGKTL
150
IINLPGSKKG
160
SQECFQFILP
170
ALPHAIDLLR
180
DAIVKVKEVH
190
DELEDLPSPP
200
PPLSPPPTTS
210
PHKQTEDKGV
220
QCEEEEEEKK
230
DSGVASTEDS
240
SSSHITAAAI
250
AAKIPDSIIS
260
RGVQVLPRDT
270
ASLSTTPSES
280
PRAQATSRLS
290
TASCPTPKVQ
300
SRCSSKENIL
310
RASHSAVDIT
320
KVARRHRMSP
330
FPLTSMDKAF
340
ITVLEMTPVL
350
GTEIINYRDG
360
MGRVLAQDVY
370
AKDNLPPFPA
380
SVKDGYAVRA
390
ADGPGDRFII
400
GESQAGEQPT
410
QTVMPGQVMR
420
VTTGAPIPCG
430
ADAVVQVEDT
440
ELIRESDDGT
450
EELEVRILVQ
460
ARPGQDIRPI
470
GHDIKRGECV
480
LAKGTHMGPS
490
EIGLLATVGV
500
TEVEVNKFPV
510
VAVMSTGNEL
520
LNPEDDLLPG
530
KIRDSNRSTL
540
LATIQEHGYP
550
TINLGIVGDN
560
PDDLLNALNE
570
GISRADVIIT
580
SGGVSMGEKD
590
YLKQVLDIDL
600
HAQIHFGRVF
610
MKPGLPTTFA
620
TLDIDGVRKI
630
IFALPGNPVS
640
AVVTCNLFVV
650
PALRKMQGIL
660
DPRPTIIKAR
670
LSCDVKLDPR
680
PEYHRCILTW
690
HHQEPLPWAQ
700
STGNQMSSRL
710
MSMRSANGLL
720
MLPPKTEQYV
730
ELHKGEVVDV
MVIGRL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0009898 | cytoplasmic side of plasma membrane |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0043197 | dendritic spine |
| Cellular Component | GO:0098982 | GABA-ergic synapse |
| Cellular Component | GO:0098690 | glycinergic synapse |
| Cellular Component | GO:0060077 | inhibitory synapse |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:0045211 | postsynaptic membrane |
| Cellular Component | GO:0099572 | postsynaptic specialization |
| Cellular Component | GO:0099091 | postsynaptic specialization, intracellular component |
| Cellular Component | GO:0097060 | synaptic membrane |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0061598 | molybdopterin adenylyltransferase activity |
| Molecular Function | GO:0043546 | molybdopterin cofactor binding |
| Molecular Function | GO:0061599 | molybdopterin molybdotransferase activity |
| Molecular Function | GO:0008940 | nitrate reductase activity |
| Molecular Function | GO:0030674 | protein-macromolecule adaptor activity |
| Molecular Function | GO:0005102 | signaling receptor binding |
| Biological Process | GO:0045184 | establishment of protein localization |
| Biological Process | GO:0007529 | establishment of synaptic specificity at neuromuscular junction |
| Biological Process | GO:0097112 | gamma-aminobutyric acid receptor clustering |
| Biological Process | GO:0072579 | glycine receptor clustering |
| Biological Process | GO:0006777 | Mo-molybdopterin cofactor biosynthetic process |
| Biological Process | GO:0099645 | neurotransmitter receptor localization to postsynaptic specialization membrane |
| Biological Process | GO:0010038 | response to metal ion |
| Biological Process | GO:0007416 | synapse assembly |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.