Search Results

Overview

Uniprot IDQ9NQZ2
Protein NameSomething about silencing protein 10
Gene NameUTP3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
12 SRRRGAAKWAAVRAK
133 SLSWGQRKKLYYDTD
134 LSWGQRKKLYYDTDY
144 YDTDYGSKSRGRQSQ
380 KAKLKYYKEIEDRQK
417 AITYQIAKNRGLTPR

Function

Essential for gene silencing: has a role in the structure of silenced chromatin. Plays a role in the developing brain (By similarity). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797)

Protein Sequence

10 MVGRSRRRGA 20 AKWAAVRAKA 30 GPTLTDENGD 40 DLGLPPSPGD 50 TSYYQDQVDD 60 FHEARSRAAL 70 AKGWNEVQSG 80 DEEDGEEEEE 90 EVLALDMDDE 100 DDEDGGNAGE 110 EEEEENADDD 120 GGSSVQSEAE 130 ASVDPSLSWG 140 QRKKLYYDTD 150 YGSKSRGRQS 160 QQEAEEEERE 170 EEEEAQIIQR 180 RLAQALQEDD 190 FGVAWVEAFA 200 KPVPQVDEAE 210 TRVVKDLAKV 220 SVKEKLKMLR 230 KESPELLELI 240 EDLKVKLTEV 250 KDELEPLLEL 260 VEQGIIPPGK 270 GSQYLRTKYN 280 LYLNYCSNIS 290 FYLILKARRV 300 PAHGHPVIER 310 LVTYRNLINK 320 LSVVDQKLSS 330 EIRHLLTLKD 340 DAVKKELIPK 350 AKSTKPKPKS 360 VSKTSAAACA 370 VTDLSDDSDF 380 DEKAKLKYYK 390 EIEDRQKLKR 400 KKEENSTEEQ 410 ALEDQNAKRA 420 ITYQIAKNRG 430 LTPRRKKIDR 440 NPRVKHREKF 450 RRAKIRRRGQ 460 VREVRKEEQR 470 YSGELSGIRA GVKKSIKLK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0032040 small-subunit processome
Molecular Function GO:0003723 RNA binding
Biological Process GO:0007420 brain development
Biological Process GO:0006325 chromatin organization
Biological Process GO:0030490 maturation of SSU-rRNA
Biological Process GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Biological Process GO:0042274 ribosomal small subunit biogenesis

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.