Search Results

Overview

Uniprot IDQ9NR09
Protein NameDual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6
Gene NameBIRC6
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
2265 KEKIQSNKGSSYKLL
3455 DRIQALLKWVSDSAR
3946 RGRTIPDKIGSTSGA

Function

Anti-apoptotic protein known as inhibitor of apoptosis (IAP) which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase (PubMed:14765125, PubMed:15200957, PubMed:18329369). Unlike most IAPs, does not contain a RING domain and it is not a RING-type E3 ligase (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Instead acts as a dual E2/E3 enzyme that combines ubiquitin conjugating (E2) and ubiquitin ligase (E3) activities in a single polypeptide (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitination is mediated by a non-canonical E1 ubiquitin activating enzyme UBA6 (PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates CASP3, CASP7 and CASP9 and inhibits their caspase activity; also ubiquitinates their procaspases but to a weaker extent (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates pro-apoptotic factors DIABLO/SMAC and HTRA2 (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). DIABLO/SMAC antagonizes the caspase inhibition activity of BIRC6 by competing for the same binding sites as the caspases (PubMed:18329369, PubMed:36758106). Ubiquitinates the autophagy protein MAP1LC3B; this activity is also inhibited by DIABLO/SMAC (PubMed:36758105). Important regulator for the final stages of cytokinesis (PubMed:18329369). Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification (PubMed:18329369)

Protein Sequence

10 MVTGGGAAPP 20 GTVTEPLPSV 30 IVLSAGRKMA 40 AAAAAASGPG 50 CSSAAGAGAA 60 GVSEWLVLRD 70 GCMHCDADGL 80 HSLSYHPALN 90 AILAVTSRGT 100 IKVIDGTSGA 110 TLQASALSAK 120 PGGQVKCQYI 130 SAVDKVIFVD 140 DYAVGCRKDL 150 NGILLLDTAL 160 QTPVSKQDDV 170 VQLELPVTEA 180 QQLLSACLEK 190 VDISSTEGYD 200 LFITQLKDGL 210 KNTSHETAAN 220 HKVAKWATVT 230 FHLPHHVLKS 240 IASAIVNELK 250 KINQNVAALP 260 VASSVMDRLS 270 YLLPSARPEL 280 GVGPGRSVDR 290 SLMYSEANRR 300 ETFTSWPHVG 310 YRWAQPDPMA 320 QAGFYHQPAS 330 SGDDRAMCFT 340 CSVCLVCWEP 350 TDEPWSEHER 360 HSPNCPFVKG 370 EHTQNVPLSV 380 TLATSPAQFP 390 CTDGTDRISC 400 FGSGSCPHFL 410 AAATKRGKIC 420 IWDVSKLMKV 430 HLKFEINAYD 440 PAIVQQLILS 450 GDPSSGVDSR 460 RPTLAWLEDS 470 SSCSDIPKLE 480 GDSDDLLEDS 490 DSEEHSRSDS 500 VTGHTSQKEA 510 MEVSLDITAL 520 SILQQPEKLQ 530 WEIVANVLED 540 TVKDLEELGA 550 NPCLTNSKSE 560 KTKEKHQEQH 570 NIPFPCLLAG 580 GLLTYKSPAT 590 SPISSNSHRS 600 LDGLSRTQGE 610 SISEQGSTDN 620 ESCTNSELNS 630 PLVRRTLPVL 640 LLYSIKESDE 650 KAGKIFSQMN 660 NIMSKSLHDD 670 GFTVPQIIEM 680 ELDSQEQLLL 690 QDPPVTYIQQ 700 FADAAANLTS 710 PDSEKWNSVF 720 PKPGTLVQCL 730 RLPKFAEEEN 740 LCIDSITPCA 750 DGIHLLVGLR 760 TCPVESLSAI 770 NQVEALNNLN 780 KLNSALCNRR 790 KGELESNLAV 800 VNGANISVIQ 810 HESPADVQTP 820 LIIQPEQRNV 830 SGGYLVLYKM 840 NYATRIVTLE 850 EEPIKIQHIK 860 DPQDTITSLI 870 LLPPDILDNR 880 EDDCEEPIED 890 MQLTSKNGFE 900 REKTSDISTL 910 GHLVITTQGG 920 YVKILDLSNF 930 EILAKVEPPK 940 KEGTEEQDTF 950 VSVIYCSGTD 960 RLCACTKGGE 970 LHFLQIGGTC 980 DDIDEADILV 990 DGSLSKGIEP 1000 SSEGSKPLSN 1010 PSSPGISGVD 1020 LLVDQPFTLE 1030 ILTSLVELTR 1040 FETLTPRFSA 1050 TVPPCWVEVQ 1060 QEQQQRRHPQ 1070 HLHQQHHGDA 1080 AQHTRTWKLQ 1090 TDSNSWDEHV 1100 FELVLPKACM 1110 VGHVDFKFVL 1120 NSNITNIPQI 1130 QVTLLKNKAP 1140 GLGKVNALNI 1150 EVEQNGKPSL 1160 VDLNEEMQHM 1170 DVEESQCLRL 1180 CPFLEDHKED 1190 ILCGPVWLAS 1200 GLDLSGHAGM 1210 LTLTSPKLVK 1220 GMAGGKYRSF 1230 LIHVKAVNER 1240 GTEEICNGGM 1250 RPVVRLPSLK 1260 HQSNKGYSLA 1270 SLLAKVAAGK 1280 EKSSNVKNEN 1290 TSGTRKSENL 1300 RGCDLLQEVS 1310 VTIRRFKKTS 1320 ISKERVQRCA 1330 MLQFSEFHEK 1340 LLNTLCRKTD 1350 DGQITEHAQS 1360 LVLDTLCWLA 1370 GVHSNGPGSS 1380 KEGNENLLSK 1390 TRKFLSDIVR 1400 VCFFEAGRSI 1410 AHKCARFLAL 1420 CISNGKCDPC 1430 QPAFGPVLLK 1440 ALLDNMSFLP 1450 AATTGGSVYW 1460 YFVLLNYVKD 1470 EDLAGCSTAC 1480 ASLLTAVSRQ 1490 LQDRLTPMEA 1500 LLQTRYGLYS 1510 SPFDPVLFDL 1520 EMSGSSCKNV 1530 YNSSIGVQSD 1540 EIDLSDVLSG 1550 NGKVSSCTAA 1560 EGSFTSLTGL 1570 LEVEPLHFTC 1580 VSTSDGTRIE 1590 RDDAMSSFGV 1600 TPAVGGLSSG 1610 TVGEASTALS 1620 SAAQVALQSL 1630 SHAMASAEQQ 1640 LQVLQEKQQQ 1650 LLKLQQQKAK 1660 LEAKLHQTTA 1670 AAAAAASAVG 1680 PVHNSVPSNP 1690 VAAPGFFIHP 1700 SDVIPPTPKT 1710 TPLFMTPPLT 1720 PPNEAVSVVI 1730 NAELAQLFPG 1740 SVIDPPAVNL 1750 AAHNKNSNKS 1760 RMNPLGSGLA 1770 LAISHASHFL 1780 QPPPHQSIII 1790 ERMHSGARRF 1800 VTLDFGRPIL 1810 LTDVLIPTCG 1820 DLASLSIDIW 1830 TLGEEVDGRR 1840 LVVATDISTH 1850 SLILHDLIPP 1860 PVCRFMKITV 1870 IGRYGSTNAR 1880 AKIPLGFYYG 1890 HTYILPWESE 1900 LKLMHDPLKG 1910 EGESANQPEI 1920 DQHLAMMVAL 1930 QEDIQCRYNL 1940 ACHRLETLLQ 1950 SIDLPPLNSA 1960 NNAQYFLRKP 1970 DKAVEEDSRV 1980 FSAYQDCIQL 1990 QLQLNLAHNA 2000 VQRLKVALGA 2010 SRKMLSETSN 2020 PEDLIQTSST 2030 EQLRTIIRYL 2040 LDTLLSLLHA 2050 SNGHSVPAVL 2060 QSTFHAQACE 2070 ELFKHLCISG 2080 TPKIRLHTGL 2090 LLVQLCGGER 2100 WWGQFLSNVL 2110 QELYNSEQLL 2120 IFPQDRVFML 2130 LSCIGQRSLS 2140 NSGVLESLLN 2150 LLDNLLSPLQ 2160 PQLPMHRRTE 2170 GVLDIPMISW 2180 VVMLVSRLLD 2190 YVATVEDEAA 2200 AAKKPLNGNQ 2210 WSFINNNLHT 2220 QSLNRSSKGS 2230 SSLDRLYSRK 2240 IRKQLVHHKQ 2250 QLNLLKAKQK 2260 ALVEQMEKEK 2270 IQSNKGSSYK 2280 LLVEQAKLKQ 2290 ATSKHFKDLI 2300 RLRRTAEWSR 2310 SNLDTEVTTA 2320 KESPEIEPLP 2330 FTLAHERCIS 2340 VVQKLVLFLL 2350 SMDFTCHADL 2360 LLFVCKVLAR 2370 IANATRPTIH 2380 LCEIVNEPQL 2390 ERLLLLLVGT 2400 DFNRGDISWG 2410 GAWAQYSLTC 2420 MLQDILAGEL 2430 LAPVAAEAME 2440 EGTVGDDVGA 2450 TAGDSDDSLQ 2460 QSSVQLLETI 2470 DEPLTHDITG 2480 APPLSSLEKD 2490 KEIDLELLQD 2500 LMEVDIDPLD 2510 IDLEKDPLAA 2520 KVFKPISSTW 2530 YDYWGADYGT 2540 YNYNPYIGGL 2550 GIPVAKPPAN 2560 TEKNGSQTVS 2570 VSVSQALDAR 2580 LEVGLEQQAE 2590 LMLKMMSTLE 2600 ADSILQALTN 2610 TSPTLSQSPT 2620 GTDDSLLGGL 2630 QAANQTSQLI 2640 IQLSSVPMLN 2650 VCFNKLFSML 2660 QVHHVQLESL 2670 LQLWLTLSLN 2680 SSSTGNKENG 2690 ADIFLYNANR 2700 IPVISLNQAS 2710 ITSFLTVLAW 2720 YPNTLLRTWC 2730 LVLHSLTLMT 2740 NMQLNSGSSS 2750 AIGTQESTAH 2760 LLVSDPNLIH 2770 VLVKFLSGTS 2780 PHGTNQHSPQ 2790 VGPTATQAMQ 2800 EFLTRLQVHL 2810 SSTCPQIFSE 2820 FLLKLIHILS 2830 TERGAFQTGQ 2840 GPLDAQVKLL 2850 EFTLEQNFEV 2860 VSVSTISAVI 2870 ESVTFLVHHY 2880 ITCSDKVMSR 2890 SGSDSSVGAR 2900 ACFGGLFANL 2910 IRPGDAKAVC 2920 GEMTRDQLMF 2930 DLLKLVNILV 2940 QLPLSGNREY 2950 SARVSVTTNT 2960 TDSVSDEEKV 2970 SGGKDGNGSS 2980 TSVQGSPAYV 2990 ADLVLANQQI 3000 MSQILSALGL 3010 CNSSAMAMII 3020 GASGLHLTKH 3030 ENFHGGLDAI 3040 SVGDGLFTIL 3050 TTLSKKASTV 3060 HMMLQPILTY 3070 MACGYMGRQG 3080 SLATCQLSEP 3090 LLWFILRVLD 3100 TSDALKAFHD 3110 MGGVQLICNN 3120 MVTSTRAIVN 3130 TARSMVSTIM 3140 KFLDSGPNKA 3150 VDSTLKTRIL 3160 ASEPDNAEGI 3170 HNFAPLGTIT 3180 SSSPTAQPAE 3190 VLLQATPPHR 3200 RARSAAWSYI 3210 FLPEEAWCDL 3220 TIHLPAAVLL 3230 KEIHIQPHLA 3240 SLATCPSSVS 3250 VEVSADGVNM 3260 LPLSTPVVTS 3270 GLTYIKIQLV 3280 KAEVASAVCL 3290 RLHRPRDAST 3300 LGLSQIKLLG 3310 LTAFGTTSSA 3320 TVNNPFLPSE 3330 DQVSKTSIGW 3340 LRLLHHCLTH 3350 ISDLEGMMAS 3360 AAAPTANLLQ 3370 TCAALLMSPY 3380 CGMHSPNIEV 3390 VLVKIGLQST 3400 RIGLKLIDIL 3410 LRNCAASGSD 3420 PTDLNSPLLF 3430 GRLNGLSSDS 3440 TIDILYQLGT 3450 TQDPGTKDRI 3460 QALLKWVSDS 3470 ARVAAMKRSG 3480 RMNYMCPNSS 3490 TVEYGLLMPS 3500 PSHLHCVAAI 3510 LWHSYELLVE 3520 YDLPALLDQE 3530 LFELLFNWSM 3540 SLPCNMVLKK 3550 AVDSLLCSMC 3560 HVHPNYFSLL 3570 MGWMGITPPP 3580 VQCHHRLSMT 3590 DDSKKQDLSS 3600 SLTDDSKNAQ 3610 APLALTESHL 3620 ATLASSSQSP 3630 EAIKQLLDSG 3640 LPSLLVRSLA 3650 SFCFSHISSS 3660 ESIAQSIDIS 3670 QDKLRRHHVP 3680 QQCNKMPITA 3690 DLVAPILRFL 3700 TEVGNSHIMK 3710 DWLGGSEVNP 3720 LWTALLFLLC 3730 HSGSTSGSHN 3740 LGAQQTSARS 3750 ASLSSAATTG 3760 LTTQQRTAIE 3770 NATVAFFLQC 3780 ISCHPNNQKL 3790 MAQVLCELFQ 3800 TSPQRGNLPT 3810 SGNISGFIRR 3820 LFLQLMLEDE 3830 KVTMFLQSPC 3840 PLYKGRINAT 3850 SHVIQHPMYG 3860 AGHKFRTLHL 3870 PVSTTLSDVL 3880 DRVSDTPSIT 3890 AKLISEQKDD 3900 KEKKNHEEKE 3910 KVKAENGFQD 3920 NYSVVVASGL 3930 KSQSKRAVSA 3940 TPPRPPSRRG 3950 RTIPDKIGST 3960 SGAEAANKII 3970 TVPVFHLFHK 3980 LLAGQPLPAE 3990 MTLAQLLTLL 4000 YDRKLPQGYR 4010 SIDLTVKLGS 4020 RVITDPSLSK 4030 TDSYKRLHPE 4040 KDHGDLLASC 4050 PEDEALTPGD 4060 ECMDGILDES 4070 LLETCPIQSP 4080 LQVFAGMGGL 4090 ALIAERLPML 4100 YPEVIQQVSA 4110 PVVTSTTQEK 4120 PKDSDQFEWV 4130 TIEQSGELVY 4140 EAPETVAAEP 4150 PPIKSAVQTM 4160 SPIPAHSLAA 4170 FGLFLRLPGY 4180 AEVLLKERKH 4190 AQCLLRLVLG 4200 VTDDGEGSHI 4210 LQSPSANVLP 4220 TLPFHVLRSL 4230 FSTTPLTTDD 4240 GVLLRRMALE 4250 IGALHLILVC 4260 LSALSHHSPR 4270 VPNSSVNQTE 4280 PQVSSSHNPT 4290 STEEQQLYWA 4300 KGTGFGTGST 4310 ASGWDVEQAL 4320 TKQRLEEEHV 4330 TCLLQVLASY 4340 INPVSSAVNG 4350 EAQSSHETRG 4360 QNSNALPSVL 4370 LELLSQSCLI 4380 PAMSSYLRND 4390 SVLDMARHVP 4400 LYRALLELLR 4410 AIASCAAMVP 4420 LLLPLSTENG 4430 EEEEEQSECQ 4440 TSVGTLLAKM 4450 KTCVDTYTNR 4460 LRSKRENVKT 4470 GVKPDASDQE 4480 PEGLTLLVPD 4490 IQKTAEIVYA 4500 ATTSLRQANQ 4510 EKKLGEYSKK 4520 AAMKPKPLSV 4530 LKSLEEKYVA 4540 VMKKLQFDTF 4550 EMVSEDEDGK 4560 LGFKVNYHYM 4570 SQVKNANDAN 4580 SAARARRLAQ 4590 EAVTLSTSLP 4600 LSSSSSVFVR 4610 CDEERLDIMK 4620 VLITGPADTP 4630 YANGCFEFDV 4640 YFPQDYPSSP 4650 PLVNLETTGG 4660 HSVRFNPNLY 4670 NDGKVCLSIL 4680 NTWHGRPEEK 4690 WNPQTSSFLQ 4700 VLVSVQSLIL 4710 VAEPYFNEPG 4720 YERSRGTPSG 4730 TQSSREYDGN 4740 IRQATVKWAM 4750 LEQIRNPSPC 4760 FKEVIHKHFY 4770 LKRVEIMAQC 4780 EEWIADIQQY 4790 SSDKRVGRTM 4800 SHHAAALKRH 4810 TAQLREELLK 4820 LPCPEGLDPD 4830 TDDAPEVCRA 4840 TTGAEETLMH 4850 DQVKPSSSKE LPSDFQL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0072686 mitotic spindle
Cellular Component GO:0005813 centrosome
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005768 endosome
Cellular Component GO:0090543 Flemming body
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0016020 membrane
Cellular Component GO:0005815 microtubule organizing center
Cellular Component GO:0030496 midbody
Cellular Component GO:0005634 nucleus
Cellular Component GO:0000922 spindle pole
Cellular Component GO:0005802 trans-Golgi network
Molecular Function GO:0004869 cysteine-type endopeptidase inhibitor activity
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0061631 ubiquitin conjugating enzyme activity
Molecular Function GO:0004842 ubiquitin-protein transferase activity
Biological Process GO:0006915 apoptotic process
Biological Process GO:0051301 cell division
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Biological Process GO:0001890 placenta development
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0016567 protein ubiquitination
Biological Process GO:0042127 regulation of cell population proliferation
Biological Process GO:0032465 regulation of cytokinesis

Reference

[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.