Search Results

Overview

Uniprot ID	Q9NR12
Protein Name	PDZ and LIM domain protein 7
Gene Name	PDLIM7
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
114	APSVSLNKTARPFGA
22	GFRLQGGKDFNVPLS
238	AERYAPDKTSTVLTR
93	PVQSKPQKASAPAAD

Function

May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity)

Protein Sequence

10 MDSFKVVLEG 20 PAPWGFRLQG 30 GKDFNVPLSI 40 SRLTPGGKAA 50 QAGVAVGDWV 60 LSIDGENAGS 70 LTHIEAQNKI 80 RACGERLSLG 90 LSRAQPVQSK 100 PQKASAPAAD 110 PPRYTFAPSV 120 SLNKTARPFG 130 APPPADSAPQ 140 QNGQPLRPLV 150 PDASKQRLME 160 NTEDWRPRPG 170 TGQSRSFRIL 180 AHLTGTEFMQ 190 DPDEEHLKKS 200 SQVPRTEAPA 210 PASSTPQEPW 220 PGPTAPSPTS 230 RPPWAVDPAF 240 AERYAPDKTS 250 TVLTRHSQPA 260 TPTPLQSRTS 270 IVQAAAGGVP 280 GGGSNNGKTP 290 VCHQCHKVIR 300 GRYLVALGHA 310 YHPEEFVCSQ 320 CGKVLEEGGF 330 FEEKGAIFCP 340 PCYDVRYAPS 350 CAKCKKKITG 360 EIMHALKMTW 370 HVHCFTCAAC 380 KTPIRNRAFY 390 MEEGVPYCER 400 DYEKMFGTKC 410 HGCDFKIDAG 420 DRFLEALGFS 430 WHDTCFVCAI 440 CQINLEGKTF 450 YSKKDRPLCK SHAFSHV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0015629	actin cytoskeleton
Cellular Component	GO:0005912	adherens junction
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0031941	filamentous actin
Cellular Component	GO:0005925	focal adhesion
Cellular Component	GO:0001726	ruffle
Cellular Component	GO:0001725	stress fiber
Cellular Component	GO:0030018	Z disc
Molecular Function	GO:0003779	actin binding
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0051371	muscle alpha-actinin binding
Biological Process	GO:0030036	actin cytoskeleton organization
Biological Process	GO:0030154	cell differentiation
Biological Process	GO:0007507	heart development
Biological Process	GO:0061061	muscle structure development
Biological Process	GO:0001503	ossification
Biological Process	GO:0006898	receptor-mediated endocytosis

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.