Search Results
Overview
| Uniprot ID | Q9NR28 |
|---|---|
| Protein Name | Diablo IAP-binding mitochondrial protein |
| Gene Name | DIABLO |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 146 | ARAEMTSKHQEYLKL |
| 203 | EVHQLSRKAETKLAE |
Function
Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/BRUCE by inhibiting its binding to caspases (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106)
Protein Sequence
10
MAALKSWLSR
20
SVTSFFRYRQ
30
CLCVPVVANF
40
KKRCFSELIR
50
PWHKTVTIGF
60
GVTLCAVPIA
70
QKSEPHSLSS
80
EALMRRAVSL
90
VTDSTSTFLS
100
QTTYALIEAI
110
TEYTKAVYTL
120
TSLYRQYTSL
130
LGKMNSEEED
140
EVWQVIIGAR
150
AEMTSKHQEY
160
LKLETTWMTA
170
VGLSEMAAEA
180
AYQTGADQAS
190
ITARNHIQLV
200
KLQVEEVHQL
210
SRKAETKLAE
220
AQIEELRQKT
230
QEEGEERAES
EQEAYLRED
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0035631 | CD40 receptor complex |
| Cellular Component | GO:0009898 | cytoplasmic side of plasma membrane |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005758 | mitochondrial intermembrane space |
| Cellular Component | GO:0005739 | mitochondrion |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0097190 | apoptotic signaling pathway |
| Biological Process | GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors |
| Biological Process | GO:0097193 | intrinsic apoptotic signaling pathway |
| Biological Process | GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress |
| Biological Process | GO:0051402 | neuron apoptotic process |
| Biological Process | GO:0043065 | positive regulation of apoptotic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.