Search Results
Overview
| Uniprot ID | Q9NR33 |
|---|---|
| Protein Name | DNA polymerase epsilon subunit 4 |
| Gene Name | POLE4 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 90 | YCCAQQGKRKTLQRR |
Function
Accessory component of the DNA polymerase epsilon complex (PubMed:10801849). Participates in DNA repair and in chromosomal DNA replication (By similarity)
Protein Sequence
10
MAAAAAAGSG
20
TPREEEGPAG
30
EAAASQPQAP
40
TSVPGARLSR
50
LPLARVKALV
60
KADPDVTLAG
70
QEAIFILARA
80
AELFVETIAK
90
DAYCCAQQGK
100
RKTLQRRDLD
110
NAIEAVDEFA
FLEGTLD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0140672 | ATAC complex |
| Cellular Component | GO:0008622 | epsilon DNA polymerase complex |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0003887 | DNA-directed DNA polymerase activity |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Biological Process | GO:0006261 | DNA-templated DNA replication |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.
[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.