Search Results

Overview

Uniprot ID	Q9NR50
Protein Name	Translation initiation factor eIF2B subunit gamma
Gene Name	EIF2B3
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
189	IKGSILQKHPRIRFH

Function

Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit (PubMed:25858979, PubMed:27023709, PubMed:31048492). Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed (PubMed:25858979, PubMed:31048492)

Protein Sequence

10 MEFQAVVMAV 20 GGGSRMTDLT 30 SSIPKPLLPV 40 GNKPLIWYPL 50 NLLERVGFEE 60 VIVVTTRDVQ 70 KALCAEFKMK 80 MKPDIVCIPD 90 DADMGTADSL 100 RYIYPKLKTD 110 VLVLSCDLIT 120 DVALHEVVDL 130 FRAYDASLAM 140 LMRKGQDSIE 150 PVPGQKGKKK 160 AVEQRDFIGV 170 DSTGKRLLFM 180 ANEADLDEEL 190 VIKGSILQKH 200 PRIRFHTGLV 210 DAHLYCLKKY 220 IVDFLMENGS 230 ITSIRSELIP 240 YLVRKQFSSA 250 SSQQGQEEKE 260 EDLKKKELKS 270 LDIYSFIKEA 280 NTLNLAPYDA 290 CWNACRGDRW 300 EDLSRSQVRC 310 YVHIMKEGLC 320 SRVSTLGLYM 330 EANRQVPKLL 340 SALCPEEPPV 350 HSSAQIVSKH 360 LVGVDSLIGP 370 ETQIGEKSSI 380 KRSVIGSSCL 390 IKDRVTITNC 400 LLMNSVTVEE 410 GSNIQGSVIC 420 NNAVIEKGAD 430 IKDCLIGSGQ 440 RIEAKAKRVN 450 EVIVGNDQLM EI

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005851	eukaryotic translation initiation factor 2B complex
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity
Molecular Function	GO:0003743	translation initiation factor activity
Biological Process	GO:0002183	cytoplasmic translational initiation
Biological Process	GO:0014003	oligodendrocyte development
Biological Process	GO:0045948	positive regulation of translational initiation
Biological Process	GO:0009749	response to glucose
Biological Process	GO:0009408	response to heat
Biological Process	GO:0043434	response to peptide hormone
Biological Process	GO:0050852	T cell receptor signaling pathway
Biological Process	GO:0006413	translational initiation

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.