Overview
| Uniprot ID | Q9NRA8 |
|---|
| Protein Name | Eukaryotic translation initiation factor 4E transporter |
|---|
| Gene Name | EIF4ENIF1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 758 |
SSPTTNSKLSALQRS |
Function
EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671)
Protein Sequence
10
MDRRSMGETE
20
SGDAFLDLKK
30
PPASKCPHRY
40
TKEELLDIKE
50
LPHSKQRPSC
60
LSEKYDSDGV
70
WDPEKWHASL
80
YPASGRSSPV
90
ESLKKELDTD
100
RPSLVRRIVD
110
PRERVKEDDL
120
DVVLSPQRRS
130
FGGGCHVTAA
140
VSSRRSGSPL
150
EKDSDGLRLL
160
GGRRIGSGRI
170
ISARTFEKDH
180
RLSDKDLRDL
190
RDRDRERDFK
200
DKRFRREFGD
210
SKRVFGERRR
220
NDSYTEEEPE
230
WFSAGPTSQS
240
ETIELTGFDD
250
KILEEDHKGR
260
KRTRRRTASV
270
KEGIVECNGG
280
VAEEDEVEVI
290
LAQEPAADQE
300
VPRDAVLPEQ
310
SPGDFDFNEF
320
FNLDKVPCLA
330
SMIEDVLGEG
340
SVSASRFSRW
350
FSNPSRSGSR
360
SSSLGSTPHE
370
ELERLAGLEQ
380
AILSPGQNSG
390
NYFAPIPLED
400
HAENKVDILE
410
MLQKAKVDLK
420
PLLSSLSANK
430
EKLKESSHSG
440
VVLSVEEVEA
450
GLKGLKVDQQ
460
VKNSTPFMAE
470
HLEETLSAVT
480
NNRQLKKDGD
490
MTAFNKLVST
500
MKASGTLPSQ
510
PKVSRNLESH
520
LMSPAEIPGQ
530
PVPKNILQEL
540
LGQPVQRPAS
550
SNLLSGLMGS
560
LEPTTSLLGQ
570
RAPSPPLSQV
580
FQTRAASADY
590
LRPRIPSPIG
600
FTPGPQQLLG
610
DPFQGMRKPM
620
SPITAQMSQL
630
ELQQAALEGL
640
ALPHDLAVQA
650
ANFYQPGFGK
660
PQVDRTRDGF
670
RNRQQRVTKS
680
PAPVHRGNSS
690
SPAPAASITS
700
MLSPSFTPTS
710
VIRKMYESKE
720
KSKEEPASGK
730
AALGDSKEDT
740
QKASEENLLS
750
SSSVPSADRD
760
SSPTTNSKLS
770
ALQRSSCSTP
780
LSQANRYTKE
790
QDYRPKATGR
800
KTPTLASPVP
810
TTPFLRPVHQ
820
VPLVPHVPMV
830
RPAHQLHPGL
840
VQRMLAQGVH
850
PQHLPSLLQT
860
GVLPPGMDLS
870
HLQGISGPIL
880
GQPFYPLPAA
890
SHPLLNPRPG
900
TPLHLAMVQQ
910
QLQRSVLHPP
920
GSGSHAAAVS
930
VQTTPQNVPS
940
RSGLPHMHSQ
950
LEHRPSQRSS
960
SPVGLAKWFG
970
SDVLQQPLPS
980
MPAKVISVDE
LEYRQ
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0016607 |
nuclear speck |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0000932 |
P-body |
| Cellular Component |
GO:0016605 |
PML body |
| Molecular Function |
GO:0019900 |
kinase binding |
| Molecular Function |
GO:0003729 |
mRNA binding |
| Molecular Function |
GO:0005049 |
nuclear export signal receptor activity |
| Molecular Function |
GO:0003723 |
RNA binding |
| Biological Process |
GO:0035278 |
miRNA-mediated gene silencing by inhibition of translation |
| Biological Process |
GO:0048255 |
mRNA stabilization |
| Biological Process |
GO:0106289 |
negative regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA |
| Biological Process |
GO:0017148 |
negative regulation of translation |
| Biological Process |
GO:0033962 |
P-body assembly |
| Biological Process |
GO:0060213 |
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening |
| Biological Process |
GO:0006606 |
protein import into nucleus |
Reference
PMID: N/A