Search Results
Overview
| Uniprot ID | Q9NRF8 |
|---|---|
| Protein Name | CTP synthase 2 |
| Gene Name | CTPS2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 137 | KVPVDGNKEEPQICV |
Function
CTP synthase involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen (PubMed:10899599, PubMed:16179339, PubMed:31873303, PubMed:34583994). Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides (PubMed:10899599, PubMed:16179339)
Protein Sequence
10
MKYILVTGGV
20
ISGIGKGIIA
30
SSIGTILKSC
40
GLRVTAIKID
50
PYINIDAGTF
60
SPYEHGEVFV
70
LNDGGEVDLD
80
LGNYERFLDI
90
NLYKDNNITT
100
GKIYQHVINK
110
ERRGDYLGKT
120
VQVVPHITDA
130
VQEWVMNQAK
140
VPVDGNKEEP
150
QICVIELGGT
160
IGDIEGMPFV
170
EAFRQFQFKA
180
KRENFCNIHV
190
SLVPQLSATG
200
EQKTKPTQNS
210
VRALRGLGLS
220
PDLIVCRSST
230
PIEMAVKEKI
240
SMFCHVNPEQ
250
VICIHDVSST
260
YRVPVLLEEQ
270
SIVKYFKERL
280
HLPIGDSASN
290
LLFKWRNMAD
300
RYERLQKICS
310
IALVGKYTKL
320
RDCYASVFKA
330
LEHSALAINH
340
KLNLMYIDSI
350
DLEKITETED
360
PVKFHEAWQK
370
LCKADGILVP
380
GGFGIRGTLG
390
KLQAISWART
400
KKIPFLGVCL
410
GMQLAVIEFA
420
RNCLNLKDAD
430
STEFRPNAPV
440
PLVIDMPEHN
450
PGNLGGTMRL
460
GIRRTVFKTE
470
NSILRKLYGD
480
VPFIEERHRH
490
RFEVNPNLIK
500
QFEQNDLSFV
510
GQDVDGDRME
520
IIELANHPYF
530
VGVQFHPEFS
540
SRPMKPSPPY
550
LGLLLAATGN
560
LNAYLQQGCK
570
LSSSDRYSDA
580
SDDSFSEPRI
AELEIS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0097268 | cytoophidium |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0003883 | CTP synthase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0044210 | 'de novo' CTP biosynthetic process |
| Biological Process | GO:0006241 | CTP biosynthetic process |
| Biological Process | GO:0019856 | pyrimidine nucleobase biosynthetic process |
| Biological Process | GO:0006220 | pyrimidine nucleotide metabolic process |
Reference
PMID: N/A