Search Results

Overview

Uniprot ID	Q9NRG0
Protein Name	Chromatin accessibility complex protein 1
Gene Name	CHRAC1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
102	PKKILASKYLKMLKE
105	ILASKYLKMLKEEKR

Function

Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1. Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex (PubMed:14759371)

Protein Sequence

10 MADVVVGKDK 20 GGEQRLISLP 30 LSRIRVIMKS 40 SPEVSSINQE 50 ALVLTAKATE 60 LFVQCLATYS 70 YRHGSGKEKK 80 VLTYSDLANT 90 AQQSETFQFL 100 ADILPKKILA 110 SKYLKMLKEE 120 KREEDEENDN 130 DNESDHDEAD S

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0008623	CHRAC
Cellular Component	GO:0008622	epsilon DNA polymerase complex
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0005721	pericentric heterochromatin
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity
Molecular Function	GO:0046982	protein heterodimerization activity
Biological Process	GO:0006338	chromatin remodeling
Biological Process	GO:0006261	DNA-templated DNA replication
Biological Process	GO:0006334	nucleosome assembly
Biological Process	GO:0006275	regulation of DNA replication

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.