Overview
| Uniprot ID | Q9NRI5 |
|---|
| Protein Name | Disrupted in schizophrenia 1 protein |
|---|
| Gene Name | DISC1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 482 |
RMFVLEAKDQQLRRE |
Function
Involved in the regulation of multiple aspects of embryonic and adult neurogenesis (PubMed:19303846, PubMed:19502360). Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus (By similarity). Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance (PubMed:19303846). Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation (By similarity). Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A (By similarity). Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development (PubMed:19502360). Inhibits ATF4 transcription factor activity in neurons by disrupting ATF4 dimerization and DNA-binding (By similarity). Plays a role, together with PCNT, in the microtubule network formation (PubMed:18955030)
Protein Sequence
10
MPGGGPQGAP
20
AAAGGGGVSH
30
RAGSRDCLPP
40
AACFRRRRLA
50
RRPGYMRSST
60
GPGIGFLSPA
70
VGTLFRFPGG
80
VSGEESHHSE
90
SRARQCGLDS
100
RGLLVRSPVS
110
KSAAAPTVTS
120
VRGTSAHFGI
130
QLRGGTRLPD
140
RLSWPCGPGS
150
AGWQQEFAAM
160
DSSETLDASW
170
EAACSDGARR
180
VRAAGSLPSA
190
ELSSNSCSPG
200
CGPEVPPTPP
210
GSHSAFTSSF
220
SFIRLSLGSA
230
GERGEAEGCP
240
PSREAESHCQ
250
SPQEMGAKAA
260
SLDGPHEDPR
270
CLSRPFSLLA
280
TRVSADLAQA
290
ARNSSRPERD
300
MHSLPDMDPG
310
SSSSLDPSLA
320
GCGGDGSSGS
330
GDAHSWDTLL
340
RKWEPVLRDC
350
LLRNRRQMEV
360
ISLRLKLQKL
370
QEDAVENDDY
380
DKAETLQQRL
390
EDLEQEKISL
400
HFQLPSRQPA
410
LSSFLGHLAA
420
QVQAALRRGA
430
TQQASGDDTH
440
TPLRMEPRLL
450
EPTAQDSLHV
460
SITRRDWLLQ
470
EKQQLQKEIE
480
ALQARMFVLE
490
AKDQQLRREI
500
EEQEQQLQWQ
510
GCDLTPLVGQ
520
LSLGQLQEVS
530
KALQDTLASA
540
GQIPFHAEPP
550
ETIRSLQERI
560
KSLNLSLKEI
570
TTKVCMSEKF
580
CSTLRKKVND
590
IETQLPALLE
600
AKMHAISGNH
610
FWTAKDLTEE
620
IRSLTSEREG
630
LEGLLSKLLV
640
LSSRNVKKLG
650
SVKEDYNRLR
660
REVEHQETAY
670
ETSVKENTMK
680
YMETLKNKLC
690
SCKCPLLGKV
700
WEADLEACRL
710
LIQSLQLQEA
720
RGSLSVEDER
730
QMDDLEGAAP
740
PIPPRLHSED
750
KRKTPLKVLE
760
EWKTHLIPSL
770
HCAGGEQKEE
780
SYILSAELGE
790
KCEDIGKKLL
800
YLEDQLHTAI
810
HSHDEDLIQS
820
LRRELQMVKE
830
TLQAMILQLQ
840
PAKEAGEREA
850
AASCMTAGVH
EAQA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0044297 |
cell body |
| Cellular Component |
GO:0098793 |
presynapse |
| Cellular Component |
GO:0008021 |
synaptic vesicle |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0019894 |
kinesin binding |
| Molecular Function |
GO:0060090 |
molecular adaptor activity |
| Molecular Function |
GO:0044877 |
protein-containing complex binding |
| Biological Process |
GO:0007420 |
brain development |
| Biological Process |
GO:0060070 |
canonical Wnt signaling pathway |
| Biological Process |
GO:0021846 |
cell proliferation in forebrain |
| Biological Process |
GO:0060271 |
cilium assembly |
| Biological Process |
GO:0000226 |
microtubule cytoskeleton organization |
| Biological Process |
GO:0001764 |
neuron migration |
| Biological Process |
GO:1905515 |
non-motile cilium assembly |
| Biological Process |
GO:0045773 |
positive regulation of axon extension |
| Biological Process |
GO:0001954 |
positive regulation of cell-matrix adhesion |
| Biological Process |
GO:0002052 |
positive regulation of neuroblast proliferation |
| Biological Process |
GO:0010976 |
positive regulation of neuron projection development |
| Biological Process |
GO:0030177 |
positive regulation of Wnt signaling pathway |
| Biological Process |
GO:0071539 |
protein localization to centrosome |
| Biological Process |
GO:0021852 |
pyramidal neuron migration to cerebral cortex |
| Biological Process |
GO:0060998 |
regulation of dendritic spine development |
| Biological Process |
GO:0099175 |
regulation of postsynapse organization |
| Biological Process |
GO:0090128 |
regulation of synapse maturation |
| Biological Process |
GO:0051602 |
response to electrical stimulus |
| Biological Process |
GO:0031929 |
TOR signaling |
| Cellular Component |
GO:0090724 |
central region of growth cone |
| Cellular Component |
GO:0005813 |
centrosome |
| Cellular Component |
GO:0036064 |
ciliary basal body |
| Cellular Component |
GO:0097546 |
ciliary base |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0030286 |
dynein complex |
| Cellular Component |
GO:0098982 |
GABA-ergic synapse |
| Cellular Component |
GO:0098978 |
glutamatergic synapse |
| Cellular Component |
GO:0045111 |
intermediate filament cytoskeleton |
| Cellular Component |
GO:0005871 |
kinesin complex |
| Cellular Component |
GO:0005874 |
microtubule |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Cellular Component |
GO:0048471 |
perinuclear region of cytoplasm |
| Cellular Component |
GO:0014069 |
postsynaptic density |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.