Overview
| Uniprot ID | Q9NRK6 |
|---|
| Protein Name | ATP-binding cassette sub-family B member 10, mitochondrial |
|---|
| Gene Name | ABCB10 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 265 |
QEVAFFDKTRTGELI |
Function
ATP-dependent transporter located in the mitochondrial inner membrane that catalyzes the export of biliverdin from the mitochondrial matrix, and plays a crucial role in hemoglobin synthesis and antioxidative stress (PubMed:22085049, PubMed:28315685, PubMed:28808058, PubMed:34011630, PubMed:37041204). Participates in the early step of the heme biosynthetic process during insertion of iron into protoporphyrin IX (PPIX) (PubMed:22085049, PubMed:28808058). Involved in the stabilization of the iron transporter mitoferrin-1/SLC25A37 (By similarity). In addition may be involved in mitochondrial unfolded protein response (UPRmt) signaling pathway, although ABCB10 probably does not participate in peptide export from mitochondria (PubMed:28315685)
Protein Sequence
10
MRGPPAWPLR
20
LLEPPSPAEP
30
GRLLPVACVW
40
AAASRVPGSL
50
SPFTGLRPAR
60
LWGAGPALLW
70
GVGAARRWRS
80
GCRGGGPGAS
90
RGVLGLARLL
100
GLWARGPGSC
110
RCGAFAGPGA
120
PRLPRARFPG
130
GPAAAAWAGD
140
EAWRRGPAAP
150
PGDKGRLRPA
160
AAGLPEARKL
170
LGLAYPERRR
180
LAAAVGFLTM
190
SSVISMSAPF
200
FLGKIIDVIY
210
TNPTVDYSDN
220
LTRLCLGLSA
230
VFLCGAAANA
240
IRVYLMQTSG
250
QRIVNRLRTS
260
LFSSILRQEV
270
AFFDKTRTGE
280
LINRLSSDTA
290
LLGRSVTENL
300
SDGLRAGAQA
310
SVGISMMFFV
320
SPNLATFVLS
330
VVPPVSIIAV
340
IYGRYLRKLT
350
KVTQDSLAQA
360
TQLAEERIGN
370
VRTVRAFGKE
380
MTEIEKYASK
390
VDHVMQLARK
400
EAFARAGFFG
410
ATGLSGNLIV
420
LSVLYKGGLL
430
MGSAHMTVGE
440
LSSFLMYAFW
450
VGISIGGLSS
460
FYSELMKGLG
470
AGGRLWELLE
480
REPKLPFNEG
490
VILNEKSFQG
500
ALEFKNVHFA
510
YPARPEVPIF
520
QDFSLSIPSG
530
SVTALVGPSG
540
SGKSTVLSLL
550
LRLYDPASGT
560
ISLDGHDIRQ
570
LNPVWLRSKI
580
GTVSQEPILF
590
SCSIAENIAY
600
GADDPSSVTA
610
EEIQRVAEVA
620
NAVAFIRNFP
630
QGFNTVVGEK
640
GVLLSGGQKQ
650
RIAIARALLK
660
NPKILLLDEA
670
TSALDAENEY
680
LVQEALDRLM
690
DGRTVLVIAH
700
RLSTIKNANM
710
VAVLDQGKIT
720
EYGKHEELLS
730
KPNGIYRKLM
NKQSFISA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
| Cellular Component |
GO:0031966 |
mitochondrial membrane |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Molecular Function |
GO:0140359 |
ABC-type transporter activity |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0016887 |
ATP hydrolysis activity |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Molecular Function |
GO:0042803 |
protein homodimerization activity |
| Biological Process |
GO:0048821 |
erythrocyte development |
| Biological Process |
GO:0170037 |
export from the mitochondrion |
| Biological Process |
GO:0006783 |
heme biosynthetic process |
| Biological Process |
GO:0006839 |
mitochondrial transport |
| Biological Process |
GO:0034514 |
mitochondrial unfolded protein response |
| Biological Process |
GO:0045648 |
positive regulation of erythrocyte differentiation |
| Biological Process |
GO:0070455 |
positive regulation of heme biosynthetic process |
| Biological Process |
GO:0046985 |
positive regulation of hemoglobin biosynthetic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.