Search Results

Overview

Uniprot IDQ9NRL2
Protein NameBromodomain adjacent to zinc finger domain protein 1A
Gene NameBAZ1A
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1183 YCVRPKLKTVPEGDW
1277 LPVKTRGKLSSSFSS
1304 RSQQSTPKTTVSSKT
1310 PKTTVSSKTGRSLRK
1317 KTGRSLRKINSAPPT
1396 RSVNIASKLSLQESE
1552 VSTPPAAKKSRI***
1553 STPPAAKKSRI****
294 QEDNVANKQTLASYR
598 LSNPSLVKKLSSTSV

Function

Regulatory subunit of the ATP-dependent ACF-1 and ACF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and slide edge- and center-positioned histone octamers away from their original location on the DNA template to facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:17099699, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:17099699, PubMed:28801535). The ACF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the ACF-5 ISWI chromatin remodeling complex (PubMed:28801535). Has a role in sensing the length of DNA which flank nucleosomes, which modulates the nucleosome spacing activity of the ACF-5 ISWI chromatin remodeling complex (PubMed:17099699). Involved in DNA replication and together with SMARCA5/SNF2H is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). May have a role in nuclear receptor-mediated transcription repression (PubMed:17519354)

Protein Sequence

10 MPLLHRKPFV 20 RQKPPADLRP 30 DEEVFYCKVT 40 NEIFRHYDDF 50 FERTILCNSL 60 VWSCAVTGRP 70 GLTYQEALES 80 EKKARQNLQS 90 FPEPLIIPVL 100 YLTSLTHRSR 110 LHEICDDIFA 120 YVKDRYFVEE 130 TVEVIRNNGA 140 RLQCRILEVL 150 PPSHQNGFAN 160 GHVNSVDGET 170 IIISDSDDSE 180 TQSCSFQNGK 190 KKDAIDPLLF 200 KYKVQPTKKE 210 LHESAIVKAT 220 QISRRKHLFS 230 RDKLKLFLKQ 240 HCEPQDGVIK 250 IKASSLSTYK 260 IAEQDFSYFF 270 PDDPPTFIFS 280 PANRRRGRPP 290 KRIHISQEDN 300 VANKQTLASY 310 RSKATKERDK 320 LLKQEEMKSL 330 AFEKAKLKRE 340 KADALEAKKK 350 EKEDKEKKRE 360 ELKKIVEEER 370 LKKKEEKERL 380 KVEREKEREK 390 LREEKRKYVE 400 YLKQWSKPRE 410 DMECDDLKEL 420 PEPTPVKTRL 430 PPEIFGDALM 440 VLEFLNAFGE 450 LFDLQDEFPD 460 GVTLEVLEEA 470 LVGNDSEGPL 480 CELLFFFLTA 490 IFQAIAEEEE 500 EVAKEQLTDA 510 DTKDLTEALD 520 EDADPTKSAL 530 SAVASLAAAW 540 PQLHQGCSLK 550 SLDLDSCTLS 560 EILRLHILAS 570 GADVTSANAK 580 YRYQKRGGFD 590 ATDDACMELR 600 LSNPSLVKKL 610 SSTSVYDLTP 620 GEKMKILHAL 630 CGKLLTLVST 640 RDFIEDYVDI 650 LRQAKQEFRE 660 LKAEQHRKER 670 EEAAARIRKR 680 KEEKLKEQEQ 690 KMKEKQEKLK 700 EDEQRNSTAD 710 ISIGEEERED 720 FDTSIESKDT 730 EQKELDQDMV 740 TEDEDDPGSH 750 KRGRRGKRGQ 760 NGFKEFTRQE 770 QINCVTREPL 780 TADEEEALKQ 790 EHQRKEKELL 800 EKIQSAIACT 810 NIFPLGRDRM 820 YRRYWIFPSI 830 PGLFIEEDYS 840 GLTEDMLLPR 850 PSSFQNNVQS 860 QDPQVSTKTG 870 EPLMSESTSN 880 IDQGPRDHSV 890 QLPKPVHKPN 900 RWCFYSSCEQ 910 LDQLIEALNS 920 RGHRESALKE 930 TLLQEKSRIC 940 AQLARFSEEK 950 FHFSDKPQPD 960 SKPTYSRGRS 970 SNAYDPSQMC 980 AEKQLELRLR 990 DFLLDIEDRI 1000 YQGTLGAIKV 1010 TDRHIWRSAL 1020 ESGRYELLSE 1030 ENKENGIIKT 1040 VNEDVEEMEI 1050 DEQTKVIVKD 1060 RLLGIKTETP 1070 STVSTNASTP 1080 QSVSSVVHYL 1090 AMALFQIEQG 1100 IERRFLKAPL 1110 DASDSGRSYK 1120 TVLDRWRESL 1130 LSSASLSQVF 1140 LHLSTLDRSV 1150 IWSKSILNAR 1160 CKICRKKGDA 1170 ENMVLCDGCD 1180 RGHHTYCVRP 1190 KLKTVPEGDW 1200 FCPECRPKQR 1210 SRRLSSRQRP 1220 SLESDEDVED 1230 SMGGEDDEVD 1240 GDEEEGQSEE 1250 EEYEVEQDED 1260 DSQEEEEVSL 1270 PKRGRPQVRL 1280 PVKTRGKLSS 1290 SFSSRGQQQE 1300 PGRYPSRSQQ 1310 STPKTTVSSK 1320 TGRSLRKINS 1330 APPTETKSLR 1340 IASRSTRHSH 1350 GPLQADVFVE 1360 LLSPRRKRRG 1370 RKSANNTPEN 1380 SPNFPNFRVI 1390 ATKSSEQSRS 1400 VNIASKLSLQ 1410 ESESKRRCRK 1420 RQSPEPSPVT 1430 LGRRSSGRQG 1440 GVHELSAFEQ 1450 LVVELVRHDD 1460 SWPFLKLVSK 1470 IQVPDYYDII 1480 KKPIALNIIR 1490 EKVNKCEYKL 1500 ASEFIDDIEL 1510 MFSNCFEYNP 1520 RNTSEAKAGT 1530 RLQAFFHIQA 1540 QKLGLHVTPS 1550 NVDQVSTPPA AKKSRI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016590 ACF complex
Cellular Component GO:0008623 CHRAC
Cellular Component GO:0000228 nuclear chromosome
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005721 pericentric heterochromatin
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0006261 DNA-templated DNA replication
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0006334 nucleosome assembly
Biological Process GO:0045740 positive regulation of DNA replication
Biological Process GO:0006275 regulation of DNA replication
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:0031445 regulation of heterochromatin formation
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.