Overview
| Uniprot ID | Q9NRX1 |
|---|
| Protein Name | RNA-binding protein PNO1 |
|---|
| Gene Name | PNO1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 236 |
ILGNPPSKVYGNIRA |
Function
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA (PubMed:25851604)
Protein Sequence
10
MESEMETQSA
20
RAEEGFTQVT
30
RKGGRRAKKR
40
QAEQLSAAGE
50
GGDAGRMDTE
60
EARPAKRPVF
70
PPLCGDGLLS
80
GKEETRKIPV
90
PANRYTPLKE
100
NWMKIFTPIV
110
EHLGLQIRFN
120
LKSRNVEIRT
130
CKETKDVSAL
140
TKAADFVKAF
150
ILGFQVEDAL
160
ALIRLDDLFL
170
ESFEITDVKP
180
LKGDHLSRAI
190
GRIAGKGGKT
200
KFTIENVTRT
210
RIVLADVKVH
220
ILGSFQNIKM
230
ARTAICNLIL
240
GNPPSKVYGN
250
IRAVASRSAD
RF
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005730 |
nucleolus |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0032040 |
small-subunit processome |
| Molecular Function |
GO:0003723 |
RNA binding |
| Biological Process |
GO:0030490 |
maturation of SSU-rRNA |
| Biological Process |
GO:0042274 |
ribosomal small subunit biogenesis |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.