Search Results
Overview
| Uniprot ID | Q9NRX4 |
|---|---|
| Protein Name | 14 kDa phosphohistidine phosphatase |
| Gene Name | PHPT1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 48 | KEIVRGYKWAEYHAD |
Function
Exhibits phosphohistidine phosphatase activity
Protein Sequence
10
MAVADLALIP
20
DVDIDSDGVF
30
KYVLIRVHSA
40
PRSGAPAAES
50
KEIVRGYKWA
60
EYHADIYDKV
70
SGDMQKQGCD
80
CECLGGGRIS
90
HQSQDKKIHV
100
YGYSMAYGPA
110
QHAISTEKIK
120
AKYPDYEVTW
ANDGY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0061851 | leading edge of lamellipodium |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0019855 | calcium channel inhibitor activity |
| Molecular Function | GO:0004857 | enzyme inhibitor activity |
| Molecular Function | GO:0101006 | protein histidine phosphatase activity |
| Molecular Function | GO:0044325 | transmembrane transporter binding |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0097581 | lamellipodium organization |
| Biological Process | GO:0050860 | negative regulation of T cell receptor signaling pathway |
| Biological Process | GO:2000147 | positive regulation of cell motility |
| Biological Process | GO:0035774 | positive regulation of insulin secretion involved in cellular response to glucose stimulus |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.