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Overview

Uniprot IDQ9NS91
Protein NameE3 ubiquitin-protein ligase RAD18
Gene NameRAD18
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
156 LIKENKSKFSPQKEA
341 EIDEIHSKYRKKHKS
363 QARKGYKKIAGMSQK

Function

E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity

Protein Sequence

10 MDSLAESRWP 20 PGLAVMKTID 30 DLLRCGICFE 40 YFNIAMIIPQ 50 CSHNYCSLCI 60 RKFLSYKTQC 70 PTCCVTVTEP 80 DLKNNRILDE 90 LVKSLNFARN 100 HLLQFALESP 110 AKSPASSSSK 120 NLAVKVYTPV 130 ASRQSLKQGS 140 RLMDNFLIRE 150 MSGSTSELLI 160 KENKSKFSPQ 170 KEASPAAKTK 180 ETRSVEEIAP 190 DPSEAKRPEP 200 PSTSTLKQVT 210 KVDCPVCGVN 220 IPESHINKHL 230 DSCLSREEKK 240 ESLRSSVHKR 250 KPLPKTVYNL 260 LSDRDLKKKL 270 KEHGLSIQGN 280 KQQLIKRHQE 290 FVHMYNAQCD 300 ALHPKSAAEI 310 VREIENIEKT 320 RMRLEASKLN 330 ESVMVFTKDQ 340 TEKEIDEIHS 350 KYRKKHKSEF 360 QLLVDQARKG 370 YKKIAGMSQK 380 TVTITKEDES 390 TEKLSSVCMG 400 QEDNMTSVTN 410 HFSQSKLDSP 420 EELEPDREED 430 SSSCIDIQEV 440 LSSSESDSCN 450 SSSSDIIRDL 460 LEEEEAWEAS 470 HKNDLQDTEI 480 SPRQNRRTRA 490 AESAEIEPRN KRNRN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005813 centrosome
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0042405 nuclear inclusion body
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0097505 Rad6-Rad18 complex
Cellular Component GO:0005657 replication fork
Cellular Component GO:0035861 site of double-strand break
Molecular Function GO:0003684 damaged DNA binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0031593 polyubiquitin modification-dependent protein binding
Molecular Function GO:0044877 protein-containing complex binding
Molecular Function GO:0003697 single-stranded DNA binding
Molecular Function GO:0061630 ubiquitin protein ligase activity
Molecular Function GO:0031625 ubiquitin protein ligase binding
Molecular Function GO:0000403 Y-form DNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006974 DNA damage response
Biological Process GO:0006301 DNA damage tolerance
Biological Process GO:0006281 DNA repair
Biological Process GO:0051984 positive regulation of chromosome segregation
Biological Process GO:0051865 protein autoubiquitination
Biological Process GO:0006513 protein monoubiquitination

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.