Search Results

Overview

Uniprot IDQ9NSD9
Protein NamePhenylalanine--tRNA ligase beta subunit
Gene NameFARSB
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
107 MPDGKIQKLIITEET
47 SEKEIISKEQGNVKA
53 SKEQGNVKAAGASDV
7 *MPTVSVKRDLLFQA

Function

No function data available.

Protein Sequence

10 MPTVSVKRDL 20 LFQALGRTYT 30 DEEFDELCFE 40 FGLELDEITS 50 EKEIISKEQG 60 NVKAAGASDV 70 VLYKIDVPAN 80 RYDLLCLEGL 90 VRGLQVFKER 100 IKAPVYKRVM 110 PDGKIQKLII 120 TEETAKIRPF 130 AVAAVLRNIK 140 FTKDRYDSFI 150 ELQEKLHQNI 160 CRKRALVAIG 170 THDLDTLSGP 180 FTYTAKRPSD 190 IKFKPLNKTK 200 EYTACELMNI 210 YKTDNHLKHY 220 LHIIENKPLY 230 PVIYDSNGVV 240 LSMPPIINGD 250 HSRITVNTRN 260 IFIECTGTDF 270 TKAKIVLDII 280 VTMFSEYCEN 290 QFTVEAAEVV 300 FPNGKSHTFP 310 ELAYRKEMVR 320 ADLINKKVGI 330 RETPENLAKL 340 LTRMYLKSEV 350 IGDGNQIEIE 360 IPPTRADIIH 370 ACDIVEDAAI 380 AYGYNNIQMT 390 LPKTYTIANQ 400 FPLNKLTELL 410 RHDMAAAGFT 420 EALTFALCSQ 430 EDIADKLGVD 440 ISATKAVHIS 450 NPKTAEFQVA 460 RTTLLPGLLK 470 TIAANRKMPL 480 PLKLFEISDI 490 VIKDSNTDVG 500 AKNYRHLCAV 510 YYNKNPGFEI 520 IHGLLDRIMQ 530 LLDVPPGEDK 540 GGYVIKASEG 550 PAFFPGRCAE 560 IFARGQSVGK 570 LGVLHPDVIT 580 KFELTMPCSS LEINVGPFL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0016020 membrane
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0009328 phenylalanine-tRNA ligase complex
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0000287 magnesium ion binding
Molecular Function GO:0004826 phenylalanine-tRNA ligase activity
Molecular Function GO:0003723 RNA binding
Biological Process GO:0006432 phenylalanyl-tRNA aminoacylation
Biological Process GO:0051290 protein heterotetramerization
Biological Process GO:0006412 translation

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[3] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.