Search Results

Overview

Uniprot IDQ9NSE4
Protein NameIsoleucine--tRNA ligase, mitochondrial
Gene NameIARS2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
130 HVGHALNKILKDIAN
189 KKARSFAKAAIEKQK
233 TFYQMYDKGLVYRSY
241 GLVYRSYKPVFWSPS
458 KNLLKEEKLVHSYPY
649 ARKRAPYKTVIVHGF
661 HGFTLGEKGEKMSKS
687 NGGQDQSKEPPYGAD
781 YKQYDFGKVVRLLRT
957 TADVIELKGKFLINL
959 DVIELKGKFLINLEG

Function

Aminoacyl-tRNA synthetase that catalyzes the specific attachment of isoleucine to its cognate tRNA (tRNA(Ile))

Protein Sequence

10 MRWGLRPRGP 20 GAAALATARS 30 LWGTPRLPCS 40 PGWQGATKRL 50 LVRSVSGASN 60 HQPNSNSGRY 70 RDTVLLPQTS 80 FPMKLLGRQQ 90 PDTELEIQQK 100 CGFSELYSWQ 110 RERKVKTEFC 120 LHDGPPYANG 130 DPHVGHALNK 140 ILKDIANRFH 150 MMNGSKIHFV 160 PGWDCHGLPI 170 EIKVLSELGR 180 EAQNLSAMEI 190 RKKARSFAKA 200 AIEKQKSAFI 210 RWGIMADWNN 220 CYYTFDGKYE 230 AKQLRTFYQM 240 YDKGLVYRSY 250 KPVFWSPSSR 260 TALAEAELEY 270 NPEHVSRSIY 280 VKFPLLKPSP 290 KLASLIDGSS 300 PVSILVWTTQ 310 PWTIPANEAV 320 CYMPESKYAV 330 VKCSKSGDLY 340 VLAADKVASV 350 ASTLETTFET 360 ISTLSGVDLE 370 NGTCSHPLIP 380 DKASPLLPAN 390 HVTMAKGTGL 400 VHTAPAHGME 410 DYGVASQHNL 420 PMDCLVDEDG 430 VFTDVAGPEL 440 QNKAVLEEGT 450 DVVIKMLQTA 460 KNLLKEEKLV 470 HSYPYDWRTK 480 KPVVIRASKQ 490 WFINITDIKT 500 AAKELLKKVK 510 FIPGSALNGM 520 VEMMDRRPYW 530 CISRQRVWGV 540 PIPVFHHKTK 550 DEYLINSQTT 560 EHIVKLVEQH 570 GSDIWWTLPP 580 EQLLPKEVLS 590 EVGGPDALEY 600 VPGQDILDIW 610 FDSGTSWSYV 620 LPGPDQRADL 630 YLEGKDQLGG 640 WFQSSLLTSV 650 AARKRAPYKT 660 VIVHGFTLGE 670 KGEKMSKSLG 680 NVIHPDVVVN 690 GGQDQSKEPP 700 YGADVLRWWV 710 ADSNVFTEVA 720 IGPSVLNAAR 730 DDISKLRNTL 740 RFLLGNVADF 750 NPETDSIPVN 760 DMYVIDQYML 770 HLLQDLANKI 780 TELYKQYDFG 790 KVVRLLRTFY 800 TRELSNFYFS 810 IIKDRLYCEK 820 ENDPKRRSCQ 830 TALVEILDVI 840 VRSFAPILPH 850 LAEEVFQHIP 860 YIKEPKSVFR 870 TGWISTSSIW 880 KKPGLEEAVE 890 SACAMRDSFL 900 GSIPGKNAAE 910 YKVITVIEPG 920 LLFEIIEMLQ 930 SEETSSTSQL 940 NELMMASEST 950 LLAQEPREMT 960 ADVIELKGKF 970 LINLEGGDIR 980 EESSYKVIVM 990 PTTKEKCPRC 1000 WKYTAESSDT 1010 LCPRCAEVVS GK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005759 mitochondrial matrix
Molecular Function GO:0002161 aminoacyl-tRNA deacylase activity
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0004822 isoleucine-tRNA ligase activity
Molecular Function GO:0000049 tRNA binding
Biological Process GO:0006428 isoleucyl-tRNA aminoacylation
Biological Process GO:0032543 mitochondrial translation
Biological Process GO:0006418 tRNA aminoacylation for protein translation
Cellular Component GO:0005739 mitochondrion

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.