Search Results
Overview
| Uniprot ID | Q9NSI8 |
|---|---|
| Protein Name | SAM domain-containing protein SAMSN-1 |
| Gene Name | SAMSN1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 12 | KPSNVSEKEKHQKPK |
| 5 | ***MLKRKPSNVSEK |
Function
Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation (By similarity)
Protein Sequence
10
MLKRKPSNVS
20
EKEKHQKPKR
30
SSSFGNFDRF
40
RNNSLSKPDD
50
STEAHEGDPT
60
NGSGEQSKTS
70
NNGGGLGKKM
80
RAISWTMKKK
90
VGKKYIKALS
100
EEKDEEDGEN
110
AHPYRNSDPV
120
IGTHTEKVSL
130
KASDSMDSLY
140
SGQSSSSGIT
150
SCSDGTSNRD
160
SFRLDDDGPY
170
SGPFCGRARV
180
HTDFTPSPYD
190
TDSLKIKKGD
200
IIDIICKTPM
210
GMWTGMLNNK
220
VGNFKFIYVD
230
VISEEEAAPK
240
KIKANRRSNS
250
KKSKTLQEFL
260
ERIHLQEYTS
270
TLLLNGYETL
280
EDLKDIKESH
290
LIELNIENPD
300
DRRRLLSAAE
310
NFLEEEIIQE
320
QENEPEPLSL
330
SSDISLNKSQ
340
LDDCPRDSGC
350
YISSGNSDNG
360
KEDLESENLS
370
DMVHKIIITE
PSD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0001726 | ruffle |
| Molecular Function | GO:0001784 | phosphotyrosine residue binding |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0002820 | negative regulation of adaptive immune response |
| Biological Process | GO:0050869 | negative regulation of B cell activation |
| Biological Process | GO:0050732 | negative regulation of peptidyl-tyrosine phosphorylation |
| Biological Process | GO:1902531 | regulation of intracellular signal transduction |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.