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Overview

Uniprot IDQ9NSK0
Protein NameKinesin light chain 4
Gene NameKLC4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
557 QRSGSLGKIRDVLRR
572 SSELLVRKLQGTEPR

Function

Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity)

Protein Sequence

10 MSGLVLGQRD 20 EPAGHRLSQE 30 EILGSTRLVS 40 QGLEALRSEH 50 QAVLQSLSQT 60 IECLQQGGHE 70 EGLVHEKARQ 80 LRRSMENIEL 90 GLSEAQVMLA 100 LASHLSTVES 110 EKQKLRAQVR 120 RLCQENQWLR 130 DELAGTQQRL 140 QRSEQAVAQL 150 EEEKKHLEFL 160 GQLRQYDEDG 170 HTSEEKEGDA 180 TKDSLDDLFP 190 NEEEEDPSNG 200 LSRGQGATAA 210 QQGGYEIPAR 220 LRTLHNLVIQ 230 YAAQGRYEVA 240 VPLCKQALED 250 LERTSGRGHP 260 DVATMLNILA 270 LVYRDQNKYK 280 EAAHLLNDAL 290 SIRESTLGPD 300 HPAVAATLNN 310 LAVLYGKRGK 320 YKEAEPLCQR 330 ALEIREKVLG 340 TNHPDVAKQL 350 NNLALLCQNQ 360 GKYEAVERYY 370 QRALAIYEGQ 380 LGPDNPNVAR 390 TKNNLASCYL 400 KQGKYAEAET 410 LYKEILTRAH 420 VQEFGSVDDD 430 HKPIWMHAEE 440 REEMSKSRHH 450 EGGTPYAEYG 460 GWYKACKVSS 470 PTVNTTLRNL 480 GALYRRQGKL 490 EAAETLEECA 500 LRSRRQGTDP 510 ISQTKVAELL 520 GESDGRRTSQ 530 EGPGDSVKFE 540 GGEDASVAVE 550 WSGDGSGTLQ 560 RSGSLGKIRD 570 VLRRSSELLV 580 RKLQGTEPRP 590 SSSNMKRAAS 600 LNYLNQPSAA 610 PLQVSRGLSA STMDLSSSS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005871 kinesin complex
Cellular Component GO:0005874 microtubule
Molecular Function GO:0019894 kinesin binding
Biological Process GO:0007018 microtubule-based movement

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.