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Overview

Uniprot IDQ9NTI5
Protein NameSister chromatid cohesion protein PDS5 homolog B
Gene NamePDS5B
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1143 KPLSSAGKQSQTKSS
1244 LVQEQKPKGSQRSRK
1309 PKEEPTMKTSKKGSK
1318 SKKGSKKKSGPPAPE
1340 QSGNTEQKSKSKQHR
1380 KGRGRPSKTPSPSQP
418 GLAQIYKKYALQSAA
654 RAGLELLKVLSFTHP

Function

Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells

Protein Sequence

10 MAHSKTRTND 20 GKITYPPGVK 30 EISDKISKEE 40 MVRRLKMVVK 50 TFMDMDQDSE 60 EEKELYLNLA 70 LHLASDFFLK 80 HPDKDVRLLV 90 ACCLADIFRI 100 YAPEAPYTSP 110 DKLKDIFMFI 120 TRQLKGLEDT 130 KSPQFNRYFY 140 LLENIAWVKS 150 YNICFELEDS 160 NEIFTQLYRT 170 LFSVINNGHN 180 QKVHMHMVDL 190 MSSIICEGDT 200 VSQELLDTVL 210 VNLVPAHKNL 220 NKQAYDLAKA 230 LLKRTAQAIE 240 PYITNFFNQV 250 LMLGKTSISD 260 LSEHVFDLIL 270 ELYNIDSHLL 280 LSVLPQLEFK 290 LKSNDNEERL 300 QVVKLLAKMF 310 GAKDSELASQ 320 NKPLWQCYLG 330 RFNDIHVPIR 340 LECVKFASHC 350 LMNHPDLAKD 360 LTEYLKVRSH 370 DPEEAIRHDV 380 IVSIVTAAKK 390 DILLVNDHLL 400 NFVRERTLDK 410 RWRVRKEAMM 420 GLAQIYKKYA 430 LQSAAGKDAA 440 KQIAWIKDKL 450 LHIYYQNSID 460 DRLLVERIFA 470 QYMVPHNLET 480 TERMKCLYYL 490 YATLDLNAVK 500 ALNEMWKCQN 510 LLRHQVKDLL 520 DLIKQPKTDA 530 SVKAIFSKVM 540 VITRNLPDPG 550 KAQDFMKKFT 560 QVLEDDEKIR 570 KQLEVLVSPT 580 CSCKQAEGCV 590 REITKKLGNP 600 KQPTNPFLEM 610 IKFLLERIAP 620 VHIDTESISA 630 LIKQVNKSID 640 GTADDEDEGV 650 PTDQAIRAGL 660 ELLKVLSFTH 670 PISFHSAETF 680 ESLLACLKMD 690 DEKVAEAALQ 700 IFKNTGSKIE 710 EDFPHIRSAL 720 LPVLHHKSKK 730 GPPRQAKYAI 740 HCIHAIFSSK 750 ETQFAQIFEP 760 LHKSLDPSNL 770 EHLITPLVTI 780 GHIALLAPDQ 790 FAAPLKSLVA 800 TFIVKDLLMN 810 DRLPGKKTTK 820 LWVPDEEVSP 830 ETMVKIQAIK 840 MMVRWLLGMK 850 NNHSKSGTST 860 LRLLTTILHS 870 DGDLTEQGKI 880 SKPDMSRLRL 890 AAGSAIVKLA 900 QEPCYHEIIT 910 LEQYQLCALA 920 INDECYQVRQ 930 VFAQKLHKGL 940 SRLRLPLEYM 950 AICALCAKDP 960 VKERRAHARQ 970 CLVKNINVRR 980 EYLKQHAAVS 990 EKLLSLLPEY 1000 VVPYTIHLLA 1010 HDPDYVKVQD 1020 IEQLKDVKEC 1030 LWFVLEILMA 1040 KNENNSHAFI 1050 RKMVENIKQT 1060 KDAQGPDDAK 1070 MNEKLYTVCD 1080 VAMNIIMSKS 1090 TTYSLESPKD 1100 PVLPARFFTQ 1110 PDKNFSNTKN 1120 YLPPEMKSFF 1130 TPGKPKTTNV 1140 LGAVNKPLSS 1150 AGKQSQTKSS 1160 RMETVSNASS 1170 SSNPSSPGRI 1180 KGRLDSSEMD 1190 HSENEDYTMS 1200 SPLPGKKSDK 1210 RDDSDLVRSE 1220 LEKPRGRKKT 1230 PVTEQEEKLG 1240 MDDLTKLVQE 1250 QKPKGSQRSR 1260 KRGHTASESD 1270 EQQWPEEKRL 1280 KEDILENEDE 1290 QNSPPKKGKR 1300 GRPPKPLGGG 1310 TPKEEPTMKT 1320 SKKGSKKKSG 1330 PPAPEEEEEE 1340 ERQSGNTEQK 1350 SKSKQHRVSR 1360 RAQQRAESPE 1370 SSAIESTQST 1380 PQKGRGRPSK 1390 TPSPSQPKKN 1400 VRVGRSKQAA 1410 TKENDSSEEV 1420 DVFQGSSPVD 1430 DIPQEETEEE 1440 EVSTVNVRRR SAKRERR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005694 chromosome
Cellular Component GO:0000775 chromosome, centromeric region
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0140670 cohesin unloader activity
Molecular Function GO:0003677 DNA binding
Biological Process GO:0051301 cell division
Biological Process GO:0008283 cell population proliferation
Biological Process GO:0000724 double-strand break repair via homologous recombination
Biological Process GO:0007064 mitotic sister chromatid cohesion
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0042127 regulation of cell population proliferation

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[5] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[6] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[7] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.