Search Results

Overview

Uniprot ID	Q9NTJ3
Protein Name	Structural maintenance of chromosomes protein 4
Gene Name	SMC4
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
4	****MPRKGTQPSTA
607	LDAIIQEKKSGRIPG
608	DAIIQEKKSGRIPGI

Function

Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases

Protein Sequence

10 MPRKGTQPST 20 ARRREEGPPP 30 PSPDGASSDA 40 EPEPPSGRTE 50 SPATAAETAS 60 EELDNRSLEE 70 ILNSIPPPPP 80 PAMTNEAGAP 90 RLMITHIVNQ 100 NFKSYAGEKI 110 LGPFHKRFSC 120 IIGPNGSGKS 130 NVIDSMLFVF 140 GYRAQKIRSK 150 KLSVLIHNSD 160 EHKDIQSCTV 170 EVHFQKIIDK 180 EGDDYEVIPN 190 SNFYVSRTAC 200 RDNTSVYHIS 210 GKKKTFKDVG 220 NLLRSHGIDL 230 DHNRFLILQG 240 EVEQIAMMKP 250 KGQTEHDEGM 260 LEYLEDIIGC 270 GRLNEPIKVL 280 CRRVEILNEH 290 RGEKLNRVKM 300 VEKEKDALEG 310 EKNIAIEFLT 320 LENEIFRKKN 330 HVCQYYIYEL 340 QKRIAEMETQ 350 KEKIHEDTKE 360 INEKSNILSN 370 EMKAKNKDVK 380 DTEKKLNKIT 390 KFIEENKEKF 400 TQLDLEDVQV 410 REKLKHATSK 420 AKKLEKQLQK 430 DKEKVEEFKS 440 IPAKSNNIIN 450 ETTTRNNALE 460 KEKEKEEKKL 470 KEVMDSLKQE 480 TQGLQKEKES 490 REKELMGFSK 500 SVNEARSKMD 510 VAQSELDIYL 520 SRHNTAVSQL 530 TKAKEALIAA 540 SETLKERKAA 550 IRDIEGKLPQ 560 TEQELKEKEK 570 ELQKLTQEET 580 NFKSLVHDLF 590 QKVEEAKSSL 600 AMNRSRGKVL 610 DAIIQEKKSG 620 RIPGIYGRLG 630 DLGAIDEKYD 640 VAISSCCHAL 650 DYIVVDSIDI 660 AQECVNFLKR 670 QNIGVATFIG 680 LDKMAVWAKK 690 MTEIQTPENT 700 PRLFDLVKVK 710 DEKIRQAFYF 720 ALRDTLVADN 730 LDQATRVAYQ 740 KDRRWRVVTL 750 QGQIIEQSGT 760 MTGGGSKVMK 770 GRMGSSLVIE 780 ISEEEVNKME 790 SQLQNDSKKA 800 MQIQEQKVQL 810 EERVVKLRHS 820 EREMRNTLEK 830 FTASIQRLIE 840 QEEYLNVQVK 850 ELEANVLATA 860 PDKKKQKLLE 870 ENVSAFKTEY 880 DAVAEKAGKV 890 EAEVKRLHNT 900 IVEINNHKLK 910 AQQDKLDKIN 920 KQLDECASAI 930 TKAQVAIKTA 940 DRNLQKAQDS 950 VLRTEKEIKD 960 TEKEVDDLTA 970 ELKSLEDKAA 980 EVVKNTNAAE 990 ESLPEIQKEH 1000 RNLLQELKVI 1010 QENEHALQKD 1020 ALSIKLKLEQ 1030 IDGHIAEHNS 1040 KIKYWHKEIS 1050 KISLHPIEDN 1060 PIEEISVLSP 1070 EDLEAIKNPD 1080 SITNQIALLE 1090 ARCHEMKPNL 1100 GAIAEYKKKE 1110 ELYLQRVAEL 1120 DKITYERDSF 1130 RQAYEDLRKQ 1140 RLNEFMAGFY 1150 IITNKLKENY 1160 QMLTLGGDAE 1170 LELVDSLDPF 1180 SEGIMFSVRP 1190 PKKSWKKIFN 1200 LSGGEKTLSS 1210 LALVFALHHY 1220 KPTPLYFMDE 1230 IDAALDFKNV 1240 SIVAFYIYEQ 1250 TKNAQFIIIS 1260 LRNNMFEISD 1270 RLIGIYKTYN 1280 ITKSVAVNPK EIASKGLC

Gene Ontology

Classification	GO ID	Description
Biological Process	GO:0051301	cell division
Cellular Component	GO:0000775	chromosome, centromeric region
Cellular Component	GO:0000794	condensed nuclear chromosome
Cellular Component	GO:0000796	condensin complex
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0016607	nuclear speck
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016887	ATP hydrolysis activity
Molecular Function	GO:0003682	chromatin binding
Molecular Function	GO:0003697	single-stranded DNA binding
Biological Process	GO:0030183	B cell differentiation
Biological Process	GO:0021987	cerebral cortex development
Biological Process	GO:0071707	immunoglobulin heavy chain V-D-J recombination
Biological Process	GO:0045132	meiotic chromosome segregation
Biological Process	GO:0007076	mitotic chromosome condensation
Biological Process	GO:0000070	mitotic sister chromatid segregation
Biological Process	GO:1905821	positive regulation of chromosome condensation
Biological Process	GO:0051984	positive regulation of chromosome segregation
Biological Process	GO:1905820	positive regulation of chromosome separation

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.