Search Results

Overview

Uniprot ID	Q9NTJ5
Protein Name	Phosphatidylinositol-3-phosphatase SAC1
Gene Name	SACM1L
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
101	DFDVLSYKKTMLHLT
102	FDVLSYKKTMLHLTD
456	YAGTGALKTDFTRTG

Function

Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 4-phosphate (PtdIns(4)P) (PubMed:24209621, PubMed:27044890, PubMed:29461204, PubMed:30659099). Can also catalyze the hydrolysis of phosphatidylinositol 3-phosphate (PtdIns(3)P) and has low activity towards phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2) (By similarity). Shows a very robust PtdIns(4)P phosphatase activity when it binds PtdIns(4)P in a 'cis' configuration in the cellular environment, with much less activity seen when it binds PtdIns(4)P in 'trans' configuration (PubMed:24209621, PubMed:29461204, PubMed:30659099). PtdIns(4)P phosphatase activity (when it binds PtdIns(4)P in 'trans' configuration) is enhanced in the presence of PLEKHA3 (PubMed:30659099)

Protein Sequence

10 MATAAYEQLK 20 LHITPEKFYV 30 EACDDGADDV 40 LTIDRVSTEV 50 TLAVKKDVPP 60 SAVTRPIFGI 70 LGTIHLVAGN 80 YLIVITKKIK 90 VGEFFSHVVW 100 KATDFDVLSY 110 KKTMLHLTDI 120 QLQDNKTFLA 130 MLNHVLNVDG 140 FYFSTTYDLT 150 HTLQRLSNTS 160 PEFQEMSLLE 170 RADQRFVWNG 180 HLLRELSAQP 190 EVHRFALPVL 200 HGFITMHSCS 210 INGKYFDWIL 220 ISRRSCFRAG 230 VRYYVRGIDS 240 EGHAANFVET 250 EQIVHYNGSK 260 ASFVQTRGSI 270 PVFWSQRPNL 280 KYKPLPQISK 290 VANHMDGFQR 300 HFDSQVIIYG 310 KQVIINLINQ 320 KGSEKPLEQT 330 FATMVSSLGS 340 GMMRYIAFDF 350 HKECKNMRWD 360 RLSILLDQVA 370 EMQDELSYFL 380 VDSAGQVVAN 390 QEGVFRSNCM 400 DCLDRTNVIQ 410 SLLARRSLQA 420 QLQRLGVLHV 430 GQKLEEQDEF 440 EKIYKNAWAD 450 NANACAKQYA 460 GTGALKTDFT 470 RTGKRTHLGL 480 IMDGWNSMIR 490 YYKNNFSDGF 500 RQDSIDLFLG 510 NYSVDELESH 520 SPLSVPRDWK 530 FLALPIIMVV 540 AFSMCIICLL 550 MAGDTWTETL 560 AYVLFWGVAS 570 IGTFFIILYN 580 GKDFVDAPRL VQKEKID

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0032281	AMPA glutamate receptor complex
Cellular Component	GO:0005783	endoplasmic reticulum
Cellular Component	GO:0005789	endoplasmic reticulum membrane
Cellular Component	GO:0140268	endoplasmic reticulum-plasma membrane contact site
Cellular Component	GO:0098978	glutamatergic synapse
Cellular Component	GO:0005794	Golgi apparatus
Cellular Component	GO:0000139	Golgi membrane
Molecular Function	GO:0016791	phosphatase activity
Molecular Function	GO:0034596	phosphatidylinositol phosphate 4-phosphatase activity
Molecular Function	GO:0004438	phosphatidylinositol-3-phosphate phosphatase activity
Molecular Function	GO:0043812	phosphatidylinositol-4-phosphate phosphatase activity
Biological Process	GO:0098967	exocytic insertion of neurotransmitter receptor to postsynaptic membrane
Biological Process	GO:0006661	phosphatidylinositol biosynthetic process
Biological Process	GO:0046856	phosphatidylinositol dephosphorylation

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.